The Adenylate Cyclase-activating Activity of Cholera Toxin is Not Associated with a Nicotinamide--adenine Dinucleotide Glycohydrolase Activity

Overview

Journal Biochem J

Specialty Biochemistry

Date 1978 Sep 15

PMID 215119

Citations 1

Authors

R M Tait

S van Heyningen

Affiliations

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Abstract

The NAD+ glycohydrolase activity of cholera-toxin samples can be separated from their adenylate cyclase-activating activity by polyacrylamide-gel electrophoresis and is inhibited by sodium dodecyl sulphate (which does not inhibit the action of toxin on cells), but not by antibodies to pure toxin. It is therefore probably not a true property of the toxin.

Citing Articles

Binding of NAD+ by cholera toxin.

Galloway T, van Heyningen S Biochem J. 1987; 244(1):225-30.

PMID: 2821999 PMC: 1147975. DOI: 10.1042/bj2440225.

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