Clinical Assessment and Management of Cytopenias in Lupus Patients

Overview

Journal Curr Rheumatol Rep

Publisher Current Science

Specialty Rheumatology

Date 2011 Apr 20

PMID 21503695

Citations 10

Authors

Alana B Levine

Doruk Erkan

Affiliations

Soon will be listed here.

Abstract

Anemia, leukopenia, and/or thrombocytopenia can occur as a result of non-immune- and immune-mediated mechanisms in patients with systemic lupus erythematosus. Although the differential diagnosis of these cytopenias is broad and warrants a thorough evaluation, lupus disease activity and medications are common etiologic factors. Corticosteroids are the mainstay of initial treatment for immune-mediated hemolytic anemia and severe thrombocytopenia; immunosuppressive agents such as mycophenolate mofetil or azathioprine are often added for their steroid-sparing effects. Rituximab and intravenous immunoglobulin can be considered for refractory cytopenias based on a large body of anecdotal evidence and case series. Newer biologic agents such as belimumab or epratuzumab have yet to be studied specifically in systemic lupus erythematosus-mediated hematologic disorders.

Citing Articles

Identification and assessment of classification criteria attributes for systemic lupus erythematosus in a regional medical record data network.

Forrest N, Jackson K, Tran S, Pacheco J, Mitrovic V, Furmanchuk A Lupus Sci Med. 2023; 10(2).

PMID: 37857531 PMC: 10603333. DOI: 10.1136/lupus-2023-000963.

A Practical Perspective of the Hematologic Manifestations of Systemic Lupus Erythematosus.

Santacruz J, Mantilla M, Rueda I, Pulido S, Rodriguez-Salas G, Londono J Cureus. 2022; 14(3):e22938.

PMID: 35399432 PMC: 8986464. DOI: 10.7759/cureus.22938.

Platelet Dysfunction Diseases and Conditions: Clinical Implications and Considerations.

Kaye A, Jeha G, Moll V, Ward C, Watson M, Wynn 2nd J Adv Ther. 2020; 37(9):3707-3722.

PMID: 32729008 DOI: 10.1007/s12325-020-01453-4.

The majority of Swedish systemic lupus erythematosus patients are still affected by irreversible organ impairment: factors related to damage accrual in two regional cohorts.

Frodlund M, Reid S, Wettero J, Dahlstrom O, Sjowall C, Leonard D Lupus. 2019; 28(10):1261-1272.

PMID: 31296137 PMC: 6710616. DOI: 10.1177/0961203319860198.

A Case of Pancytopenia with Many Possible Causes: How Do You Tell Which is the Right One?.

Diaz P, Vieira M, Carneiro A, Fernandes N Eur J Case Rep Intern Med. 2019; 6(2):001012.

PMID: 30931264 PMC: 6432823. DOI: 10.12890/2019_001012.

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