Communicative and Psycholinguistic Abilities in Children with Phenylketonuria and Congenital Hypothyroidism

Overview

Journal J Appl Oral Sci

Specialty Dentistry

Date 2011 Apr 19

PMID 21499658

Citations 5

Authors

Mariana Germano Gejao

Amanda Tragueta Ferreira

Greyce Kelly Silva

Fernanda da Luz Anastacio-Pessan

Dionisia Aparecida Cusin Lamonica

Affiliations

Soon will be listed here.

Abstract

Unlabelled: The Neonatal Screening for Inborn Errors of Metabolism of the Association of Parents and Friends of Special Needs Individuals (APAE) - Bauru, Brazil, was implanted and accredited by the Brazilian Ministry of Health in 1998. It covers about 286 cities of the Bauru region and 420 collection spots. Their activities include screening, diagnosis, treatment and assistance to congenital hypothyroidism (CH) and phenylketonuria (PKU), among others. In 2005, a partnership was established with the Department of Speech-Language Pathology and Audiology, Bauru School of Dentistry, University of São Paulo, Bauru, seeking to characterize and to follow, by means of research studies, the development of the communicative abilities of children with CH and PKU.

Objective: The aim of this study was to describe communicative and psycholinguistic abilities in children with CH and PKU.

Materials And Methods: Sixty-eight children (25 children aged 1 to 120 months with PKU and 43 children aged 1 to 60 months with CH) participated in the study. The handbooks were analyzed and different instruments were applied (Observation of Communication Behavior, Early Language Milestone Scale, Peabody Picture Vocabulary Test, Gesell & Amatruda's Behavioral Development Scale, Portage Operation Inventory, Language Development Evaluation Scale, Denver Developmental Screening Test, ABFW Child Language Test-phonology and Illinois Test of Psycholinguistic Abilities), according to the children's age group and developmental level.

Results: It was observed that the children with PKU and CH at risk for alterations in their developmental abilities (motor, cognitive, linguistic, adaptive and personal-social), mainly in the first years of life. Alterations in the psycholinguistic abilities were also found, mainly after the preschool age. Attention deficits, language and cognitive alterations were more often observed in children with CH, while attention deficits with hyperactivity and alterations in the personal-social, language and motor adaptive abilities were more frequent in children with PKU.

Conclusion: CH and PKU can cause communicative and psycholinguistic alterations that compromise the communication and affect the social integration and learning of these individuals, proving the need of having these abilities assisted by a speech and language pathologist.

Citing Articles

Burden of phenylketonuria in Latin American patients: a systematic review and meta-analysis of observational studies.

Pessoa A, Martins A, Ribeiro E, Specola N, Chiesa A, Vilela D Orphanet J Rare Dis. 2022; 17(1):302.

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Neuropsychological Alterations in Patients with Congenital Hypothyroidism Treated with Levothyroxine: Linked Factors and Thyroid Hormone Hyposensitivity.

Razon-Hernandez K, Osnaya-Brizuela N, Valenzuela-Peraza A, Ontiveros-Mendoza E, Rodriguez-Serrano L, Pacheco-Rosado J J Clin Med. 2022; 11(12).

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White matter microstructural abnormalities in children with severe congenital hypothyroidism.

Cooper H, Kaden E, Halliday L, Bamiou D, Mankad K, Peters C Neuroimage Clin. 2019; 24:101980.

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Self-reported participation restrictions in normal hearing individuals in thyroid ontogeny: Evidence of subclinical changes.

Andrade C, Machado G, Magalhaes L, Pereira de Jesus E, Alves Matias E, de Oliveira Cerqueira T J Otol. 2019; 14(1):6-11.

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CONGENITAL HYPOTHYROIDISM AS A RISK FACTOR FOR CENTRAL HEARING PROCESS DISORDERS.

Andrade C, Lemos A, Machado G, Fernandes L, Silva L, de Oliveira H Rev Paul Pediatr. 2018; 37(1):82-89.

PMID: 30183803 PMC: 6362372. DOI: 10.1590/1984-0462/;2019;37;1;00014.

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