Mining MEDLINE for the Treatment of Osteoporosis

Overview

Journal J Med Syst

Specialty Medical Informatics

Date 2011 Apr 16

PMID 21494854

Citations 1

Authors

Pinar Yildirim

Cinar Ceken

Reza Hassanpour

Sadik Esmelioglu

Mehmet Resit Tolun

Affiliations

Soon will be listed here.

Abstract

In this paper, we consider the importance of osteoporosis disease in terms of medical research and pharmaceutical industry and we introduce a knowledge discovery approach regarding the treatment of osteoporosis from a historical perspective. Osteoporosis is a systemic skeletal disease in which osteoporotic fractures are associated with substantial morbidity and mortality and impaired quality of life. Osteoporosis has also higher costs, for example, longer hospital stays than many other diseases such as diabetes and heart attack and it is an attractive market for pharmaceutical companies. We use a freely available biomedical search engine leveraging text-mining technology to extract the drug names used in the treatment of osteoporosis from MEDLINE articles. We conclude that alendronate (Fosamax) and raloxifene (Evista) have the highest number of articles in MEDLINE and seem the dominating drugs for the treatment of osteoporosis in the last decade.

Citing Articles

Automatic Estimation of Osteoporotic Fracture Cases by Using Ensemble Learning Approaches.

Kilic N, Hosgormez E J Med Syst. 2015; 40(3):61.

PMID: 26660692 DOI: 10.1007/s10916-015-0413-1.

References

Lewiecki E . Current and emerging pharmacologic therapies for the management of postmenopausal osteoporosis. J Womens Health (Larchmt). 2009; 18(10):1615-26. DOI: 10.1089/jwh.2008.1086. View

Close P, Neuprez A, Reginster J . Developments in the pharmacotherapeutic management of osteoporosis. Expert Opin Pharmacother. 2006; 7(12):1603-15. DOI: 10.1517/14656566.7.12.1603. View

Cohen A, Hersh W . A survey of current work in biomedical text mining. Brief Bioinform. 2005; 6(1):57-71. DOI: 10.1093/bib/6.1.57. View

Rodriguez-Esteban R . Biomedical text mining and its applications. PLoS Comput Biol. 2009; 5(12):e1000597. PMC: 2791166. DOI: 10.1371/journal.pcbi.1000597. View

Reginster J, Deroisy R, Jupsin I . Strontium ranelate: a new paradigm in the treatment of osteoporosis. Drugs Today (Barc). 2003; 39(2):89-101. DOI: 10.1358/dot.2003.39.2.799416. View

Lippuner K . Medical treatment of vertebral osteoporosis. Eur Spine J. 2003; 12 Suppl 2:S132-41. PMC: 3591820. DOI: 10.1007/s00586-003-0608-x. View

Kubo T, Shimose S, Matsuo T, Fujimori J, Ochi M . Minodronate for the treatment of osteoporosis. Drugs Today (Barc). 2010; 46(1):33-7. DOI: 10.1358/dot.2010.46.1.1437707. View

Mulder J, Kolatkar N, LeBoff M . Drug insight: Existing and emerging therapies for osteoporosis. Nat Clin Pract Endocrinol Metab. 2006; 2(12):670-80. DOI: 10.1038/ncpendmet0325. View

Hirsimaki P, Aaltonen A, Mantyla E . Toxicity of antiestrogens. Breast J. 2002; 8(2):92-6. DOI: 10.1046/j.1524-4741.2002.08204.x. View

10.

Adachi M, Takayanagi R . [Effect of anabolic steroids on osteoporosis]. Clin Calcium. 2008; 18(10):1451-9. DOI: CliCa081014511459. View

11.

Need A, Durbridge T, Nordin B . Anabolic steroids in postmenopausal osteoporosis. Wien Med Wochenschr. 1993; 143(14-15):392-5. View

12.

Body J . [Update on treatment of postmenopausal osteoporosis]. Rev Med Brux. 2008; 29(4):301-9. View

13.

Yildirim P, Ceken C, Hassanpour R, Tolun M . Prediction of similarities among rheumatic diseases. J Med Syst. 2010; 36(3):1485-90. DOI: 10.1007/s10916-010-9609-6. View

14.

Francis R . Management of established osteoporosis. Br J Clin Pharmacol. 1998; 45(2):95-9. PMC: 1873362. DOI: 10.1046/j.1365-2125.1998.00665.x. View

15.

Wang W, Richards G, Rea S . Hybrid data mining ensemble for predicting osteoporosis risk. Conf Proc IEEE Eng Med Biol Soc. 2007; 2006:886-9. DOI: 10.1109/IEMBS.2005.1616557. View

16.

Chesnut 3rd C, Azria M, Silverman S, Engelhardt M, Olson M, Mindeholm L . Salmon calcitonin: a review of current and future therapeutic indications. Osteoporos Int. 2007; 19(4):479-91. DOI: 10.1007/s00198-007-0490-1. View

17.

Recker R, Gallagher R, MacCosbe P . Effect of dosing frequency on bisphosphonate medication adherence in a large longitudinal cohort of women. Mayo Clin Proc. 2005; 80(7):856-61. DOI: 10.4065/80.7.856. View

18.

Falagas M, Fragoulis K, Karydis I . A comparative study on the cost of new antibiotics and drugs of other therapeutic categories. PLoS One. 2006; 1:e11. PMC: 1762307. DOI: 10.1371/journal.pone.0000011. View

19.

CAMUS J, Prier A, LIEVRE J, STEPHAN J, Laveant C . [Mastocyte osteoporosis]. Rev Rhum Mal Osteoartic. 1979; 46(1):29-35. View

20.

Ananiadou S, Kell D, Tsujii J . Text mining and its potential applications in systems biology. Trends Biotechnol. 2006; 24(12):571-9. DOI: 10.1016/j.tibtech.2006.10.002. View