TGF-β Signaling in Breast Cancer Cell Invasion and Bone Metastasis

Overview

Journal J Mammary Gland Biol Neoplasia

Date 2011 Apr 16

PMID 21494783

Citations 92

Authors

Yvette Drabsch

Peter Ten Dijke

Affiliations

Soon will be listed here.

Abstract

The contribution of transforming growth factor β (TGF-β) signaling to breast cancer has been studied for more than two decades. In an early phase TGF-β may act as a tumour suppressor, while later, when cells have become resistant to its anti-mitogenic effects, the role of TGF-β switches towards malignant conversion and progression. TGF-β stimulates cell invasion and modifies the microenvironment to the advantage of cancer cells. Studies have shown that TGF-β promotes bone and lung metastasis via different mechanisms. The therapeutic strategies to target the TGF-β pathway in breast cancer are becoming increasingly clear. This review will focus on the role TGF-β in breast cancer invasion and metastasis.

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