Impact of Maternal Immunization on Influenza Hospitalizations in Infants

Overview

Journal Am J Obstet Gynecol

Publisher Elsevier

Specialty Gynecology & Obstetrics

Date 2011 Apr 16

PMID 21492825

Citations 104

Authors

Katherine A Poehling

Peter G Szilagyi

Mary A Staat

Beverly M Snively

Daniel C Payne

Carolyn B Bridges

Susan Y Chu

Laney S Light

Mila M Prill

Lyn Finelli

Marie R Griffin

Kathryn M Edwards

Affiliations

Soon will be listed here.

Abstract

We sought to determine whether maternal vaccination during pregnancy was associated with a reduced risk of laboratory-confirmed influenza hospitalizations in infants <6 months old. Active population-based, laboratory-confirmed influenza surveillance was conducted in children hospitalized with fever and/or respiratory symptoms in 3 US counties from November through April during the 2002 through 2009 influenza seasons. The exposure, influenza vaccination during pregnancy, and the outcome, positive/negative influenza testing among their hospitalized infants, were compared using logistic regression analyses. Among 1510 hospitalized infants <6 months old, 151 (10%) had laboratory-confirmed influenza and 294 (19%) mothers reported receiving influenza vaccine during pregnancy. Eighteen (12%) mothers of influenza-positive infants and 276 (20%) mothers of influenza-negative infants were vaccinated (unadjusted odds ratio, 0.53; 95% confidence interval, 0.32-0.88 and adjusted odds ratio, 0.52; 95% confidence interval, 0.30-0.91). Infants of vaccinated mothers were 45-48% less likely to have influenza hospitalizations than infants of unvaccinated mothers. Our results support the current influenza vaccination recommendation for pregnant women.

Citing Articles

Preventing Influenza Virus Infection and Severe Influenza Among Pregnant People and Infants.

Olson S, Dawood F, Grohskopf L, Ellington S J Womens Health (Larchmt). 2024; 33(12):1591-1598.

PMID: 39491270 PMC: 11727088. DOI: 10.1089/jwh.2024.0893.

Effectiveness of Influenza Vaccination During Pregnancy Against Laboratory-Confirmed Seasonal Influenza Among Infants Under 6 Months of Age in Ontario, Canada.

Fell D, Russell M, Fung S, Swayze S, Chung H, Buchan S J Infect Dis. 2024; 230(1):e80-e92.

PMID: 39052720 PMC: 11272077. DOI: 10.1093/infdis/jiad539.

Knowledge, attitudes, and perceptions of influenza vaccine among pregnant women in Minhang District, Shanghai.

Lu Y, Fu X, Xu L, Lu J Hum Vaccin Immunother. 2024; 20(1):2368944.

PMID: 38932738 PMC: 11212563. DOI: 10.1080/21645515.2024.2368944.

Safety of influenza vaccination during pregnancy: a systematic review.

Wolfe D, Fell D, Garritty C, Hamel C, Butler C, Hersi M BMJ Open. 2023; 13(9):e066182.

PMID: 37673449 PMC: 10496691. DOI: 10.1136/bmjopen-2022-066182.

Pertussis and influenza immunization: perceived attitude and decision of postpartum patients.

Hebballi N, Parker T, Garcia E, Ferguson D, Lesser S, Tsao K BMC Pregnancy Childbirth. 2022; 22(1):975.

PMID: 36577947 PMC: 9795743. DOI: 10.1186/s12884-022-05296-5.

References

Gruber W, Darden P, Still J, Lohr J, Reed G, Wright P . Evaluation of bivalent live attenuated influenza A vaccines in children 2 months to 3 years of age: safety, immunogenicity and dose-response. Vaccine. 1997; 15(12-13):1379-84. DOI: 10.1016/s0264-410x(97)00032-7. View

Poehling K, Edwards K, Weinberg G, Szilagyi P, Staat M, Iwane M . The underrecognized burden of influenza in young children. N Engl J Med. 2006; 355(1):31-40. DOI: 10.1056/NEJMoa054869. View

. ACOG committee opinion number 305, November 2004. Influenza vaccination and treatment during pregnancy. Obstet Gynecol. 2004; 104(5 Pt 1):1125-6. View

Lu P, Bridges C, Euler G, Singleton J . Influenza vaccination of recommended adult populations, U.S., 1989-2005. Vaccine. 2008; 26(14):1786-93. DOI: 10.1016/j.vaccine.2008.01.040. View

Reuman P, Ayoub E, Small P . Effect of passive maternal antibody on influenza illness in children: a prospective study of influenza A in mother-infant pairs. Pediatr Infect Dis J. 1987; 6(4):398-403. DOI: 10.1097/00006454-198704000-00011. View

Sumaya C, Gibbs R . Immunization of pregnant women with influenza A/New Jersey/76 virus vaccine: reactogenicity and immunogenicity in mother and infant. J Infect Dis. 1979; 140(2):141-6. DOI: 10.1093/infdis/140.2.141. View

Schrag S, Fiore A, Gonik B, Malik T, Reef S, Singleton J . Vaccination and perinatal infection prevention practices among obstetrician-gynecologists. Obstet Gynecol. 2003; 101(4):704-10. DOI: 10.1016/s0029-7844(03)00010-3. View

Izurieta H, Thompson W, Kramarz P, Shay D, Davis R, DeStefano F . Influenza and the rates of hospitalization for respiratory disease among infants and young children. N Engl J Med. 2000; 342(4):232-9. DOI: 10.1056/NEJM200001273420402. View

Hartert T, Neuzil K, Shintani A, Mitchel Jr E, Snowden M, Wood L . Maternal morbidity and perinatal outcomes among pregnant women with respiratory hospitalizations during influenza season. Am J Obstet Gynecol. 2004; 189(6):1705-12. DOI: 10.1016/s0002-9378(03)00857-3. View

10.

Glezen W, Taber L, Frank A, Gruber W, Piedra P . Influenza virus infections in infants. Pediatr Infect Dis J. 1997; 16(11):1065-8. DOI: 10.1097/00006454-199711000-00012. View

11.

Wright A, Holberg C, Martinez F, Morgan W, Taussig L . Breast feeding and lower respiratory tract illness in the first year of life. Group Health Medical Associates. BMJ. 1989; 299(6705):946-9. PMC: 1837795. DOI: 10.1136/bmj.299.6705.946. View

12.

Englund J, Mbawuike I, Hammill H, Holleman M, Baxter B, Glezen W . Maternal immunization with influenza or tetanus toxoid vaccine for passive antibody protection in young infants. J Infect Dis. 1993; 168(3):647-56. DOI: 10.1093/infdis/168.3.647. View

13.

Neuzil K, Zhu Y, Griffin M, Edwards K, Thompson J, Tollefson S . Burden of interpandemic influenza in children younger than 5 years: a 25-year prospective study. J Infect Dis. 2002; 185(2):147-52. DOI: 10.1086/338363. View

14.

Poehling K, Szilagyi P . Not just for kids: new paradigms for vaccine delivery in pediatrics. Acad Pediatr. 2009; 9(5):293-4. DOI: 10.1016/j.acap.2009.08.004. View

15.

Glezen W, Couch R . Interpandemic influenza in the Houston area, 1974-76. N Engl J Med. 1978; 298(11):587-92. DOI: 10.1056/NEJM197803162981103. View

16.

Fairbrother G, Cassedy A, Ortega-Sanchez I, Szilagyi P, Edwards K, Molinari N . High costs of influenza: Direct medical costs of influenza disease in young children. Vaccine. 2010; 28(31):4913-9. DOI: 10.1016/j.vaccine.2010.05.036. View

17.

Finelli L, Fiore A, Dhara R, Brammer L, Shay D, Kamimoto L . Influenza-associated pediatric mortality in the United States: increase of Staphylococcus aureus coinfection. Pediatrics. 2008; 122(4):805-11. DOI: 10.1542/peds.2008-1336. View

18.

Mouzoon M, Munoz F, Greisinger A, Brehm B, Wehmanen O, Smith F . Improving influenza immunization in pregnant women and healthcare workers. Am J Manag Care. 2010; 16(3):209-16. View

19.

Yudin M, Salaripour M, Sgro M . Pregnant women's knowledge of influenza and the use and safety of the influenza vaccine during pregnancy. J Obstet Gynaecol Can. 2009; 31(2):120-5. DOI: 10.1016/s1701-2163(16)34095-6. View

20.

Fiore A, Uyeki T, Broder K, Finelli L, Euler G, Singleton J . Prevention and control of influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices (ACIP), 2010. MMWR Recomm Rep. 2010; 59(RR-8):1-62. View