Virus-induced Differential Expression of Nuclear Receptors and Coregulators in Dendritic Cells: Implication to Interferon Production

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2011 Apr 16

PMID 21492741

Citations 7

Authors

Sinnie Sin Man Ng

Tsung-Hsien Chang

Prafullakumar Tailor

Keiko Ozato

Tomoshige Kino

Affiliations

Soon will be listed here.

Abstract

We investigated mRNA expression of 49 nuclear hormone receptors (NRs) and 35 transcriptional coregulators in mouse bone marrow-derived dendritic cells (DCs) upon infection with Newcastle Disease virus (NDV) or murine cytomegalovirus (MCMV). These viruses regulated mRNA expression of some NRs among which NOR1 and LXRα were highly induced at mRNA and protein levels. Exogenous expression of the latter NRs repressed IRF3- or IRF7-induced transactivation of the interferon β promoter and NDV infection further potentiated their repressive effect. The viral infection also significantly regulated mRNA expression of some coregulators, including HDAC1. Toll-like receptor ligands regulated NR and coregulator mRNA expression similar to the viruses. Thus, NRs and coregulators are integral components of DC-organizing anti-viral response wherein NOR1 and LXRα participate in regulating interferon production.

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References

Geyeregger R, Zeyda M, Bauer W, Kriehuber E, Saemann M, Zlabinger G . Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin. Blood. 2007; 109(10):4288-95. DOI: 10.1182/blood-2006-08-043422. View

Rolph M, Young T, Shum B, Gorgun C, Schmitz-Peiffer C, Ramshaw I . Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2. J Immunol. 2006; 177(11):7794-801. DOI: 10.4049/jimmunol.177.11.7794. View

Chinetti G, Fruchart J, Staels B . Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation. Inflamm Res. 2000; 49(10):497-505. DOI: 10.1007/s000110050622. View

Castrillo A, Joseph S, Vaidya S, Haberland M, Fogelman A, Cheng G . Crosstalk between LXR and toll-like receptor signaling mediates bacterial and viral antagonism of cholesterol metabolism. Mol Cell. 2003; 12(4):805-16. DOI: 10.1016/s1097-2765(03)00384-8. View

Pei L, Castrillo A, Tontonoz P . Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol Endocrinol. 2005; 20(4):786-94. DOI: 10.1210/me.2005-0331. View

Faveeuw C, Fougeray S, Angeli V, Fontaine J, Chinetti G, Gosset P . Peroxisome proliferator-activated receptor gamma activators inhibit interleukin-12 production in murine dendritic cells. FEBS Lett. 2000; 486(3):261-6. DOI: 10.1016/s0014-5793(00)02319-x. View

Szatmari I, Vamosi G, Brazda P, Balint B, Benko S, Szeles L . Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells. J Biol Chem. 2006; 281(33):23812-23. DOI: 10.1074/jbc.M604890200. View

Kawai T, Akira S . The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol. 2009; 21(4):317-37. PMC: 2721684. DOI: 10.1093/intimm/dxp017. View

Akira S, Uematsu S, Takeuchi O . Pathogen recognition and innate immunity. Cell. 2006; 124(4):783-801. DOI: 10.1016/j.cell.2006.02.015. View

10.

Cheng L, Chan F, Cado D, Winoto A . Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. EMBO J. 1997; 16(8):1865-75. PMC: 1169790. DOI: 10.1093/emboj/16.8.1865. View

11.

Joseph S, Bradley M, Castrillo A, Bruhn K, Mak P, Pei L . LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell. 2004; 119(2):299-309. DOI: 10.1016/j.cell.2004.09.032. View

12.

Sabol S, Brewer Jr H, Santamarina-Fojo S . The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver. J Lipid Res. 2005; 46(10):2151-67. DOI: 10.1194/jlr.M500080-JLR200. View

13.

Minucci S, Pelicci P . Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat Rev Cancer. 2006; 6(1):38-51. DOI: 10.1038/nrc1779. View

14.

Sadler A, Williams B . Interferon-inducible antiviral effectors. Nat Rev Immunol. 2008; 8(7):559-68. PMC: 2522268. DOI: 10.1038/nri2314. View

15.

Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P . Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J Biol Chem. 2005; 280(32):29256-62. DOI: 10.1074/jbc.M502606200. View

16.

Gronemeyer H, Gustafsson J, Laudet V . Principles for modulation of the nuclear receptor superfamily. Nat Rev Drug Discov. 2004; 3(11):950-64. DOI: 10.1038/nrd1551. View

17.

Tailor P, Tamura T, Kong H, Kubota T, Kubota M, Borghi P . The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8. Immunity. 2007; 27(2):228-39. PMC: 2768351. DOI: 10.1016/j.immuni.2007.06.009. View

18.

Nusinzon I, Horvath C . Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc Natl Acad Sci U S A. 2003; 100(25):14742-7. PMC: 299790. DOI: 10.1073/pnas.2433987100. View

19.

Zelcer N, Tontonoz P . Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest. 2006; 116(3):607-14. PMC: 1386115. DOI: 10.1172/JCI27883. View

20.

Mullican S, Zhang S, Konopleva M, Ruvolo V, Andreeff M, Milbrandt J . Abrogation of nuclear receptors Nr4a3 and Nr4a1 leads to development of acute myeloid leukemia. Nat Med. 2007; 13(6):730-5. DOI: 10.1038/nm1579. View