A Review on Composite Liposomal Technologies for Specialized Drug Delivery

Overview

Journal J Drug Deliv

Date 2011 Apr 15

PMID 21490759

Citations 55

Authors

Maluta S Mufamadi

Viness Pillay

Yahya E Choonara

Lisa C du Toit

Girish Modi

Dinesh Naidoo

Valence M K Ndesendo

Affiliations

Soon will be listed here.

Abstract

The combination of liposomes with polymeric scaffolds could revolutionize the current state of drug delivery technology. Although liposomes have been extensively studied as a promising drug delivery model for bioactive compounds, there still remain major drawbacks for widespread pharmaceutical application. Two approaches for overcoming the factors related to the suboptimal efficacy of liposomes in drug delivery have been suggested. The first entails modifying the liposome surface with functional moieties, while the second involves integration of pre-encapsulated drug-loaded liposomes within depot polymeric scaffolds. This attempts to provide ingenious solutions to the limitations of conventional liposomes such as short plasma half-lives, toxicity, stability, and poor control of drug release over prolonged periods. This review delineates the key advances in composite technologies that merge the concepts of depot polymeric scaffolds with liposome technology to overcome the limitations of conventional liposomes for pharmaceutical applications.

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