Allergen-specific Subcutaneous Immunotherapy in Allergic Asthma: Immunologic Mechanisms and Improvement

Overview

Journal Libyan J Med

Specialty General Medicine

Date 2011 Apr 13

PMID 21483568

Citations 8

Authors

Yousef A Taher

Paul A J Henricks

Antoon J M van Oosterhout

Affiliations

Soon will be listed here.

Abstract

Allergic asthma is a disease characterized by persistent allergen-driven airway inflammation, remodeling, and airway hyperresponsiveness. CD4(+) T-cells, especially T-helper type 2 cells, play a critical role in orchestrating the disease process through the release of the cytokines IL-4, IL-5, and IL-13. Allergen-specific immunotherapy (SIT) is currently the only treatment with a long-term effect via modifying the natural course of allergy by interfering with the underlying immunological mechanisms. However, although SIT is effective in allergic rhinitis and insect venom allergy, in allergic asthma it seldom results in complete alleviation of the symptoms. Improvement of SIT is needed to enhance its efficacy in asthmatic patients. Herein, the immunoregulatory mechanisms underlying the beneficial effects of SIT are discussed with the ultimate aim to improve its treatment efficacy.

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References

Munn D, Sharma M, Lee J, Jhaver K, Johnson T, Keskin D . Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science. 2002; 297(5588):1867-70. DOI: 10.1126/science.1073514. View

Mekala D, Alli R, Geiger T . IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4+CD25+ T lymphocytes. Proc Natl Acad Sci U S A. 2005; 102(33):11817-22. PMC: 1188008. DOI: 10.1073/pnas.0505445102. View

Belladonna M, Grohmann U, Guidetti P, Volpi C, Bianchi R, Fioretti M . Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO. J Immunol. 2006; 177(1):130-7. DOI: 10.4049/jimmunol.177.1.130. View

Hagenbaugh A, Sharma S, Dubinett S, Wei S, Aranda R, Cheroutre H . Altered immune responses in interleukin 10 transgenic mice. J Exp Med. 1997; 185(12):2101-10. PMC: 2196349. DOI: 10.1084/jem.185.12.2101. View

Cookson W . Asthma genetics. Chest. 2002; 121(3 Suppl):7S-13S. DOI: 10.1378/chest.121.3_suppl.7s-a. View

OBrien R, Byron K, Varigos G, Thomas W . House dust mite immunotherapy results in a decrease in Der p 2-specific IFN-gamma and IL-4 expression by circulating T lymphocytes. Clin Exp Allergy. 1997; 27(1):46-51. View

Wachholz P, Durham S . Induction of 'blocking' IgG antibodies during immunotherapy. Clin Exp Allergy. 2003; 33(9):1171-4. DOI: 10.1046/j.1365-2222.2003.01765.x. View

Kawamura T, Furue M . Comparative analysis of B7-1 and B7-2 expression in Langerhans cells: differential regulation by T helper type 1 and T helper type 2 cytokines. Eur J Immunol. 1995; 25(7):1913-7. DOI: 10.1002/eji.1830250718. View

Charlesworth E . Late-phase inflammation: influence on morbidity. J Allergy Clin Immunol. 1996; 98(6 Pt 3):S291-7. View

10.

Wells A, Walsh M, Bluestone J, Turka L . Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J Clin Invest. 2001; 108(6):895-903. PMC: 200935. DOI: 10.1172/JCI13220. View

11.

Barner M, Mohrs M, Brombacher F, Kopf M . Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses. Curr Biol. 1998; 8(11):669-72. DOI: 10.1016/s0960-9822(98)70256-8. View

12.

Khattri R, Cox T, Yasayko S, Ramsdell F . An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol. 2003; 4(4):337-42. DOI: 10.1038/ni909. View

13.

Akbari O, Faul J, Hoyte E, Berry G, Wahlstrom J, Kronenberg M . CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med. 2006; 354(11):1117-29. DOI: 10.1056/NEJMoa053614. View

14.

McHugh S, Deighton J, Stewart A, LACHMANN P, Ewan P . Bee venom immunotherapy induces a shift in cytokine responses from a TH-2 to a TH-1 dominant pattern: comparison of rush and conventional immunotherapy. Clin Exp Allergy. 1995; 25(9):828-38. DOI: 10.1111/j.1365-2222.1995.tb00025.x. View

15.

Noertjojo K, Dimich-Ward H, Obata H, Manfreda J, Chan-Yeung M . Exposure and sensitization to cat dander: asthma and asthma-like symptoms among adults. J Allergy Clin Immunol. 1999; 103(1 Pt 1):60-5. DOI: 10.1016/s0091-6749(99)70526-9. View

16.

Varney V, Hamid Q, Gaga M, Ying S, Jacobson M, Frew A . Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest. 1993; 92(2):644-51. PMC: 294897. DOI: 10.1172/JCI116633. View

17.

Banchereau J, Steinman R . Dendritic cells and the control of immunity. Nature. 1998; 392(6673):245-52. DOI: 10.1038/32588. View

18.

COHN L, Tepper J, Bottomly K . IL-4-independent induction of airway hyperresponsiveness by Th2, but not Th1, cells. J Immunol. 1998; 161(8):3813-6. View

19.

Grunig G, Corry D, Leach M, Seymour B, Kurup V, Rennick D . Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. J Exp Med. 1997; 185(6):1089-99. PMC: 2196229. DOI: 10.1084/jem.185.6.1089. View

20.

Grohmann U, Orabona C, Fallarino F, Vacca C, Calcinaro F, Falorni A . CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol. 2002; 3(11):1097-101. DOI: 10.1038/ni846. View