Pharmacological Inhibition of NF-κB Prolongs Lifespan of Drosophila Melanogaster

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2011 Apr 13

PMID 21483034

Citations 36

Authors

Alexey Moskalev

Mikhail Shaposhnikov

Affiliations

Soon will be listed here.

Abstract

Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

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