Synthesis and Biosynthetic Trafficking of Membrane Lipids

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2011 Apr 13

PMID 21482741

Citations 35

Authors

Tomas Blom

Pentti Somerharju

Elina Ikonen

Affiliations

Soon will be listed here.

Abstract

Eukaryotic cells can synthesize thousands of different lipid molecules that are incorporated into their membranes. This involves the activity of hundreds of enzymes with the task of creating lipid diversity. In addition, there are several, typically redundant, mechanisms to transport lipids from their site of synthesis to other cellular membranes. Biosynthetic lipid transport helps to ensure that each cellular compartment will have its characteristic lipid composition that supports the functions of the associated proteins. In this article, we provide an overview of the biosynthesis of the major lipid constituents of cell membranes, that is, glycerophospholipids, sphingolipids, and sterols, and discuss the mechanisms by which these newly synthesized lipids are delivered to their target membranes.

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References

Heikinheimo L, Somerharju P . Translocation of phosphatidylthreonine and -serine to mitochondria diminishes exponentially with increasing molecular hydrophobicity. Traffic. 2002; 3(5):367-77. DOI: 10.1034/j.1600-0854.2002.30506.x. View

Ridgway N . Oxysterol-binding proteins. Subcell Biochem. 2010; 51:159-82. DOI: 10.1007/978-90-481-8622-8_6. View

Baumann N, Sullivan D, Ohvo-Rekila H, Simonot C, Pottekat A, Klaassen Z . Transport of newly synthesized sterol to the sterol-enriched plasma membrane occurs via nonvesicular equilibration. Biochemistry. 2005; 44(15):5816-26. DOI: 10.1021/bi048296z. View

Smriti , Nemergut E, Daleke D . ATP-dependent transport of phosphatidylserine analogues in human erythrocytes. Biochemistry. 2007; 46(8):2249-59. DOI: 10.1021/bi061333x. View

Hanada K, Kumagai K, Tomishige N, Yamaji T . CERT-mediated trafficking of ceramide. Biochim Biophys Acta. 2009; 1791(7):684-91. DOI: 10.1016/j.bbalip.2009.01.006. View

Zuo Y, Zhuang D, Han R, Isaac G, Tobin J, McKee M . ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem. 2008; 283(52):36624-35. PMC: 2605993. DOI: 10.1074/jbc.M807377200. View

Futerman A, Riezman H . The ins and outs of sphingolipid synthesis. Trends Cell Biol. 2005; 15(6):312-8. DOI: 10.1016/j.tcb.2005.04.006. View

Lahiri S, Futerman A . The metabolism and function of sphingolipids and glycosphingolipids. Cell Mol Life Sci. 2007; 64(17):2270-84. PMC: 11136246. DOI: 10.1007/s00018-007-7076-0. View

Giussani P, Colleoni T, Brioschi L, Bassi R, Hanada K, Tettamanti G . Ceramide traffic in C6 glioma cells: evidence for CERT-dependent and independent transport from ER to the Golgi apparatus. Biochim Biophys Acta. 2007; 1781(1-2):40-51. DOI: 10.1016/j.bbalip.2007.11.002. View

10.

Kolter T, Sandhoff K . Lysosomal degradation of membrane lipids. FEBS Lett. 2009; 584(9):1700-12. DOI: 10.1016/j.febslet.2009.10.021. View

11.

Kol M, de Kroon A, Killian J, de Kruijff B . Transbilayer movement of phospholipids in biogenic membranes. Biochemistry. 2004; 43(10):2673-81. DOI: 10.1021/bi036200f. View

12.

Kang H, Wei J, Cohen D . PC-TP/StARD2: Of membranes and metabolism. Trends Endocrinol Metab. 2010; 21(7):449-56. PMC: 2897958. DOI: 10.1016/j.tem.2010.02.001. View

13.

Russell D . The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem. 2003; 72:137-74. DOI: 10.1146/annurev.biochem.72.121801.161712. View

14.

Ikonen E . Cellular cholesterol trafficking and compartmentalization. Nat Rev Mol Cell Biol. 2008; 9(2):125-38. DOI: 10.1038/nrm2336. View

15.

Henneberry A, Wistow G, McMaster C . Cloning, genomic organization, and characterization of a human cholinephosphotransferase. J Biol Chem. 2000; 275(38):29808-15. DOI: 10.1074/jbc.M005786200. View

16.

Wirtz K, Schouten A, Gros P . Phosphatidylinositol transfer proteins: from closed for transport to open for exchange. Adv Enzyme Regul. 2006; 46:301-11. DOI: 10.1016/j.advenzreg.2006.01.020. View

17.

Tafesse F, Ternes P, Holthuis J . The multigenic sphingomyelin synthase family. J Biol Chem. 2006; 281(40):29421-5. DOI: 10.1074/jbc.R600021200. View

18.

Kawano M, Kumagai K, Nishijima M, Hanada K . Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT. J Biol Chem. 2006; 281(40):30279-88. DOI: 10.1074/jbc.M605032200. View

19.

STOFFEL W, Bosio A . Myelin glycolipids and their functions. Curr Opin Neurobiol. 1998; 7(5):654-61. DOI: 10.1016/s0959-4388(97)80085-2. View

20.

Bose H, Lingappa V, Miller W . Rapid regulation of steroidogenesis by mitochondrial protein import. Nature. 2002; 417(6884):87-91. DOI: 10.1038/417087a. View