Reevaluating the Role of LTD in Cerebellar Motor Learning

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2011 Apr 13

PMID 21482355

Citations 164

Authors

Martijn Schonewille

Zhenyu Gao

Henk-Jan Boele

Maria F Vinueza Veloz

Wardell E Amerika

Antonia A M Simek

Marcel T De Jeu

Jordan P Steinberg

Kogo Takamiya

Freek E Hoebeek

David J Linden

Richard L Huganir

Chris I De Zeeuw

Affiliations

Soon will be listed here.

Abstract

Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfere with receptors (mGluR1) and enzymes (PKC, PKG, or αCamKII) necessary for induction of PF-PC LTD and thereby determine if cerebellar motor learning is impaired. Here, we tested three mutant mice that target the expression of PF-PC LTD by blocking internalization of AMPA receptors. Using three different cerebellar coordination tasks (adaptation of the vestibulo-ocular reflex, eyeblink conditioning, and locomotion learning on the Erasmus Ladder), we show that there is no motor learning impairment in these mutant mice that lack PF-PC LTD. These findings demonstrate that PF-PC LTD is not essential for cerebellar motor learning.

Citing Articles

Purkinje cell models: past, present and future.

Fernandez Santoro E, Karim A, Warnaar P, De Zeeuw C, Badura A, Negrello M Front Comput Neurosci. 2024; 18:1426653.

PMID: 39049990 PMC: 11266113. DOI: 10.3389/fncom.2024.1426653.

Mesoscale simulations predict the role of synergistic cerebellar plasticity during classical eyeblink conditioning.

Geminiani A, Casellato C, Boele H, Pedrocchi A, De Zeeuw C, DAngelo E PLoS Comput Biol. 2024; 20(4):e1011277.

PMID: 38574161 PMC: 11060558. DOI: 10.1371/journal.pcbi.1011277.

Climbing fibers provide essential instructive signals for associative learning.

Silva N, Ramirez-Buritica J, Pritchett D, Carey M Nat Neurosci. 2024; 27(5):940-951.

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The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning.

Schreurs B, ODell D, Wang D Biology (Basel). 2024; 13(3).

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Interactions between circuit architecture and plasticity in a closed-loop cerebellar system.

Payne H, Raymond J, Goldman M Elife. 2024; 13.

PMID: 38451856 PMC: 10919899. DOI: 10.7554/eLife.84770.

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