Functionalization of Titanium Based Metallic Biomaterials for Implant Applications

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2011 Apr 9

PMID 21476077

Citations 6

Authors

Rahul Bhola

Fengyun Su

Catherine E Krull

Affiliations

Soon will be listed here.

Abstract

Surface immobilization with active functional molecules (AFMs) on a nano-scale is a main field in the current biomaterial research. The functionalization of a vast number of substances and molecules, ranging from inorganic calcium phosphates, peptides and proteins, has been investigated throughout recent decades. However, in vitro and in vivo results are heterogeneous. This may be attributed partially to the limits of the applied immobilization methods. Therefore, this paper highlights the advantages and limitations of the currently applied methods for the biological nano-functionalization of titanium-based biomaterial surfaces. The second part describes a newer immobilization system, using the nanomechanical fixation of at least partially single-stranded nucleic acids (NAs) into an anodic titanium oxide layer as an immobilization principle and their hybridization ability for the functionalization of the surface with active functional molecules conjugated to the respective complementary NA strands.

Citing Articles

Two Gingival Cell Lines Response to Different Dental Implant Abutment Materials: An In Vitro Study.

Osman M, Kushnerev E, Alamoush R, Seymour K, Yates J Dent J (Basel). 2022; 10(10).

PMID: 36286002 PMC: 9600692. DOI: 10.3390/dj10100192.

Cytocompatible and Anti-bacterial Adhesion Nanotextured Titanium Oxide Layer on Titanium Surfaces for Dental and Orthopedic Implants.

Ferraris S, Cochis A, Cazzola M, Tortello M, Scalia A, Spriano S Front Bioeng Biotechnol. 2019; 7:103.

PMID: 31143762 PMC: 6520600. DOI: 10.3389/fbioe.2019.00103.

Enhanced biocompatibility and osteogenesis of titanium substrates immobilized with dopamine-assisted superparamagnetic FeO nanoparticles for hBMSCs.

Huang Z, Wu Z, Ma B, Yu L, He Y, Xu D R Soc Open Sci. 2018; 5(8):172033.

PMID: 30224987 PMC: 6124053. DOI: 10.1098/rsos.172033.

Bone Response to Titanium Implants Coated with Double- or Single-Stranded DNA.

Miyamoto N, Yamachika R, Sakurai T, Hayakawa T, Hosoya N Biomed Res Int. 2018; 2018:9204391.

PMID: 30009177 PMC: 6020655. DOI: 10.1155/2018/9204391.

Protein Adsorption to Titanium and Zirconia Using a Quartz Crystal Microbalance Method.

Kusakawa Y, Yoshida E, Hayakawa T Biomed Res Int. 2017; 2017:1521593.

PMID: 28246591 PMC: 5303609. DOI: 10.1155/2017/1521593.

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