Disulfiram Reactivates Latent HIV-1 in a Bcl-2-transduced Primary CD4+ T Cell Model Without Inducing Global T Cell Activation

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2011 Apr 8

PMID 21471244

Citations 125

Authors

Sifei Xing

Cynthia K Bullen

Neeta S Shroff

Liang Shan

Hung-Chih Yang

Jordyn L Manucci

Shridhar Bhat

Hao Zhang

Joseph B Margolick

Thomas C Quinn

David M Margolis

Janet D Siliciano

Robert F Siliciano

Affiliations

Soon will be listed here.

Abstract

Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels to below the detection limit. However, due to the latent reservoir in resting CD4(+) cells, HAART is not curative. Elimination of this reservoir is critical to curing HIV-1 infection. Agents that reactivate latent HIV-1 through nonspecific T cell activation are toxic. Here we demonstrate in a primary CD4(+) T cell model that the FDA-approved drug disulfiram reactivates latent HIV-1 without global T cell activation. The extent to which disulfiram reactivates latent HIV-1 in patient cells is unclear, but the drug alone or in combination may be useful in future eradication strategies.

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