Should Remaining Stockpiles of Smallpox Virus (variola) Be Destroyed?

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2011 Apr 8

PMID 21470459

Citations 7

Authors

Raymond S Weinstein

Affiliations

Soon will be listed here.

Abstract

In 2011, the World Health Organization will recommend the fate of existing smallpox stockpiles, but circumstances have changed since the complete destruction of these cultures was first proposed. Recent studies suggest that variola and its experimental surrogate, vaccinia, have a remarkable ability to modify the human immune response through complex mechanisms that scientists are only just beginning to unravel. Further study that might require intact virus is essential. Moreover, modern science now has the capability to recreate smallpox or a smallpox-like organism in the laboratory in addition to the risk of nature re-creating it as it did once before. These factors strongly suggest that relegating smallpox to the autoclave of extinction would be ill advised.

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References

Alejo A, Ruiz-Arguello M, Ho Y, Smith V, Saraiva M, Alcami A . A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus. Proc Natl Acad Sci U S A. 2006; 103(15):5995-6000. PMC: 1458686. DOI: 10.1073/pnas.0510462103. View

Rimoin A, Mulembakani P, Johnston S, Lloyd Smith J, Kisalu N, Kinkela T . Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proc Natl Acad Sci U S A. 2010; 107(37):16262-7. PMC: 2941342. DOI: 10.1073/pnas.1005769107. View

Mohamed M, Rahman M, Lanchbury J, Shattuck D, Neff C, Dufford M . Proteomic screening of variola virus reveals a unique NF-kappaB inhibitor that is highly conserved among pathogenic orthopoxviruses. Proc Natl Acad Sci U S A. 2009; 106(22):9045-50. PMC: 2683884. DOI: 10.1073/pnas.0900452106. View

Karem K, Reynolds M, Hughes C, Braden Z, Nigam P, Crotty S . Monkeypox-induced immunity and failure of childhood smallpox vaccination to provide complete protection. Clin Vaccine Immunol. 2007; 14(10):1318-27. PMC: 2168110. DOI: 10.1128/CVI.00148-07. View

Brichacek B, Vanpouille C, Trachtenberg A, Pushkarsky T, Dubrovsky L, Martin G . Long-term changes of serum chemokine levels in vaccinated military personnel. BMC Immunol. 2006; 7:21. PMC: 1578581. DOI: 10.1186/1471-2172-7-21. View

Weinstein R, Weinstein M, Alibek K, Bukrinsky M, Brichacek B . Significantly reduced CCR5-tropic HIV-1 replication in vitro in cells from subjects previously immunized with Vaccinia Virus. BMC Immunol. 2010; 11:23. PMC: 2881106. DOI: 10.1186/1471-2172-11-23. View

McFadden G . Smallpox: an ancient disease enters the modern era of virogenomics. Proc Natl Acad Sci U S A. 2004; 101(42):14994-5. PMC: 524071. DOI: 10.1073/pnas.0406207101. View

Dunlop L, Oehlberg K, Reid J, Avci D, Rosengard A . Variola virus immune evasion proteins. Microbes Infect. 2003; 5(11):1049-56. DOI: 10.1016/s1286-4579(03)00194-1. View

Mahy B, Almond J, Berns K, Chanock R, Lvov D, Pettersson R . The remaining stocks of smallpox virus should be destroyed. Science. 1993; 262(5137):1223-4. DOI: 10.1126/science.8235651. View

10.

Li Y, Carroll D, Gardner S, Walsh M, Vitalis E, Damon I . On the origin of smallpox: correlating variola phylogenics with historical smallpox records. Proc Natl Acad Sci U S A. 2007; 104(40):15787-92. PMC: 2000395. DOI: 10.1073/pnas.0609268104. View

11.

Rubins K, Hensley L, Jahrling P, Whitney A, Geisbert T, Huggins J . The host response to smallpox: analysis of the gene expression program in peripheral blood cells in a nonhuman primate model. Proc Natl Acad Sci U S A. 2004; 101(42):15190-5. PMC: 523453. DOI: 10.1073/pnas.0405759101. View

12.

Afonso C, Tulman E, Lu Z, Zsak L, Sandybaev N, Kerembekova U . The genome of camelpox virus. Virology. 2002; 295(1):1-9. DOI: 10.1006/viro.2001.1343. View

13.

Shchelkunov S . How long ago did smallpox virus emerge?. Arch Virol. 2009; 154(12):1865-71. DOI: 10.1007/s00705-009-0536-0. View

14.

Antonets D, Nepomnyashchikh T, Shchelkunov S . SECRET domain of variola virus CrmB protein can be a member of poxviral type II chemokine-binding proteins family. BMC Res Notes. 2010; 3:271. PMC: 2987869. DOI: 10.1186/1756-0500-3-271. View

15.

Rahbar R, Murooka T, Hinek A, Galligan C, Sassano A, Yu C . Vaccinia virus activation of CCR5 invokes tyrosine phosphorylation signaling events that support virus replication. J Virol. 2006; 80(14):7245-59. PMC: 1489052. DOI: 10.1128/JVI.00463-06. View

16.

Galvani A, Slatkin M . Evaluating plague and smallpox as historical selective pressures for the CCR5-Delta 32 HIV-resistance allele. Proc Natl Acad Sci U S A. 2003; 100(25):15276-9. PMC: 299980. DOI: 10.1073/pnas.2435085100. View

17.

Hummel S, Schmidt D, Kremeyer B, Herrmann B, Oppermann M . Detection of the CCR5-Delta32 HIV resistance gene in Bronze Age skeletons. Genes Immun. 2005; 6(4):371-4. DOI: 10.1038/sj.gene.6364172. View

18.

Barquet N, Domingo P . Smallpox: the triumph over the most terrible of the ministers of death. Ann Intern Med. 1997; 127(8 Pt 1):635-42. DOI: 10.7326/0003-4819-127-8_part_1-199710150-00010. View