Medical Research Council Dyspnea Scale Does Not Relate to Fibroblast Foci Profusion in IPF

Overview

Journal Diagn Pathol

Publisher Biomed Central

Specialty Pathology

Date 2011 Apr 7

PMID 21466701

Citations 1

Authors

Christina Triantafillidou

Effrosyni D Manali

Christina Magkou

Christina Sotiropoulou

Likurgos F Kolilekas

Konstantinos Kagouridis

Dimitra Rontogianni

Spyros A Papiris

Affiliations

Soon will be listed here.

Abstract

Background: In Idiopathic pulmonary fibrosis (IPF) irreversibly progressive fibrosing parenchymal damage, leads to defects in mechanics and gas exchange, manifesting with disabling exertional dyspnea. Previous studies have shown a relationship between fibroblast foci (FF) profusion and severity and survival and a relationship between dyspnea grade and severity and outcome. We hypothesized a relationship between Medical Research Council (MRC) dyspnea scale with FF, and a relationship between FF and functional parameters and survival.

Methods: We retrospectively reviewed 24 histologically documented IPF patients. Profusion of FF was semiquantitatively evaluated by two scores, Brompton and Michigan. Survival analysis was performed by fitting Cox regression models to examine the relationship of the two scores with survival and the non-parametric Spearman correlation coefficient was calculated to describe the relationships of FF scores with dyspnea scores and functional parameters.

Results: No statistically significant correlation between FF scores and the MRC scores was observed (p = 0.96 and p = 0.508 respectively). No significant correlation between FF scores and survival (p = 0.438 and p = 0.861 respectively) or any functional parameter was observed.

Conclusions: The lack of relationship between the MRC dyspnea scale and the FF might relate to the fact that dyspnea in IPF better reflects the overall of lung damage and its related consequences on mechanics and gas exchange whereas FF, one of its histological hallmarks, may not reflect its entire histology derangement also constrained by the geographically limited sampled tissue. This might be also valid for the observed lack of association between FF and survival or functional parameters.

Citing Articles

The Role of Cardiopulmonary Exercise Test in IPF Prognosis.

Triantafillidou C, Manali E, Lyberopoulos P, Kolilekas L, Kagouridis K, Gyftopoulos S Pulm Med. 2013; 2013:514817.

PMID: 24288606 PMC: 3833281. DOI: 10.1155/2013/514817.

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