Ectopic Expression of Cux1 is Associated with Reduced P27 Expression and Increased Apoptosis During Late Stage Cyst Progression Upon Inactivation of Pkd1 in Collecting Ducts

Overview

Journal Dev Dyn

Publisher Wiley

Specialty Anatomy & Histology

Date 2011 Apr 6

PMID 21465620

Citations 10

Authors

Binu M Paul

Dianne Vassmer

Aaron Taylor

Lynn Magenheimer

Carol G Carlton

Klaus B Piontek

Gregory G Germino

Gregory B Vanden Heuvel

Affiliations

Soon will be listed here.

Abstract

Polycystic kidney diseases (PKD) are inherited disorders characterized by fluid-filled cysts primarily in the kidneys. We previously reported differences between the expression of Cux1, p21, and p27 in the cpk and Pkd1 null mouse models of PKD. Embryonic lethality of Pkd1 null mice limits its study to early stages of kidney development. Therefore, we examined mice with a collecting duct specific deletion in the Pkd1 gene. Cux1 was ectopically expressed in the cyst lining epithelial cells of newborn, P7 and P15 Pkd1(CD) mice. Cux1 expression correlated with cell proliferation in early stages of cystogenesis, however, as the disease progressed, fewer cyst lining cells showed increased cell proliferation. Rather, Cux1 expression in late stage cystogenesis was associated with increased apoptosis. Taken together, our results suggest that increased Cux1 expression associated with apoptosis is a common feature of late stage cyst progression in both the cpk and Pkd1(CD) mouse models of PKD.

Citing Articles

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