Chikungunya Virus Infection

Overview

Journal Curr Infect Dis Rep

Specialty Infectious Diseases

Date 2011 Apr 6

PMID 21465340

Citations 77

Authors

Fabrice Simon

Emilie Javelle

Manuela Oliver

Isabelle Leparc-Goffart

Catherine Marimoutou

Affiliations

Soon will be listed here.

Abstract

Chikungunya virus (CHIKV) is an alphavirus transmitted by mosquitoes, mostly Aedes aegypti and Aedes albopictus. After half a century of focal outbreaks of acute febrile polyarthralgia in Africa and Asia, the disease unexpectedly spread in the past decade with large outbreaks in Africa and around the Indian Ocean and rare autochthonous transmission in temperate areas. This emergence brought new insights on its pathogenesis, notably the role of the A226V mutation that improved CHIKV fitness in Ae. albopictus and the possible CHIKV persistence in deep tissue sanctuaries for months after infection. Massive outbreaks also revealed new aspects of the acute stage: the high number of symptomatic cases, unexpected complications, mother-to-child transmission, and low lethality in debilitated patients. The follow-up of patients in epidemic areas has identified frequent, long-lasting, rheumatic disorders, including rare inflammatory joint destruction, and common chronic mood changes associated with quality-of-life impairment. Thus, the globalization of CHIKV exposes countries with Aedes mosquitoes both to brutal outbreaks of acute incapacitating episodes and endemic long-lasting disorders.

Citing Articles

Clinical manifestations associated with the chronic phase of Chikungunya Fever: A systematic review of prevalence.

Santiago R, Bavaresco S, Citrangulo S, de Andrade Medronho R, Sampaio V, Costa A PLoS Negl Trop Dis. 2025; 19(2):e0012810.

PMID: 39899618 PMC: 11825093. DOI: 10.1371/journal.pntd.0012810.

Design of therapeutic siRNAs for potential application to infection with chikungunya virus.

Adib A, Karim M Heliyon. 2025; 11(2):e41824.

PMID: 39897885 PMC: 11782961. DOI: 10.1016/j.heliyon.2025.e41824.

Emergence of ECSA-IOL E1-K211E/E2-V264A Lineage of Chikungunya virus during Malaysian 2021 outbreak.

Kalyanasundram J, Zawawi Z, Kamel K, Aroidoss E, Ellan K, Anasir M BMC Infect Dis. 2024; 24(1):1199.

PMID: 39448916 PMC: 11515639. DOI: 10.1186/s12879-024-10102-y.

Genus Linnaeus, 1758 (Diptera: Culicidae) as an Important Potential Arbovirus Vector in Brazil: An Integrative Review.

Reis L, Pampolha A, Nascimento B, Dias D, Araujo P, da Silva F Life (Basel). 2023; 13(11).

PMID: 38004319 PMC: 10672040. DOI: 10.3390/life13112179.

Chikungunya Virus, Metabolism, and Circadian Rhythmicity Interplay in Phagocytic Cells.

Alvarez-Garcia L, Sanchez-Garcia F, Vazquez-Pichardo M, Moreno-Altamirano M Metabolites. 2023; 13(11).

PMID: 37999239 PMC: 10672914. DOI: 10.3390/metabo13111143.

References

Gerardin P, Barau G, Michault A, Bintner M, Randrianaivo H, Choker G . Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Réunion. PLoS Med. 2008; 5(3):e60. PMC: 2267812. DOI: 10.1371/journal.pmed.0050060. View

Economopoulou A, Dominguez M, Helynck B, Sissoko D, Wichmann O, Quenel P . Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Réunion. Epidemiol Infect. 2008; 137(4):534-41. DOI: 10.1017/S0950268808001167. View

Muthumani K, Lankaraman K, Laddy D, Sundaram S, Chung C, Sako E . Immunogenicity of novel consensus-based DNA vaccines against Chikungunya virus. Vaccine. 2008; 26(40):5128-34. PMC: 2582145. DOI: 10.1016/j.vaccine.2008.03.060. View

Labadie K, Larcher T, Joubert C, Mannioui A, Delache B, Brochard P . Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. J Clin Invest. 2010; 120(3):894-906. PMC: 2827953. DOI: 10.1172/JCI40104. View

Chevillon C, Briant L, Renaud F, Devaux C . The Chikungunya threat: an ecological and evolutionary perspective. Trends Microbiol. 2008; 16(2):80-8. DOI: 10.1016/j.tim.2007.12.003. View

Hochedez P, Jaureguiberry S, Debruyne M, Bossi P, Hausfater P, Brucker G . Chikungunya infection in travelers. Emerg Infect Dis. 2006; 12(10):1565-7. PMC: 3290953. DOI: 10.3201/eid1210.060495. View

Simon F, Savini H, Parola P . Chikungunya: a paradigm of emergence and globalization of vector-borne diseases. Med Clin North Am. 2008; 92(6):1323-43, ix. DOI: 10.1016/j.mcna.2008.07.008. View

Niedrig M, Zeller H, Schuffenecker I, Drosten C, Emmerich P, Rumer L . International diagnostic accuracy study for the serological detection of chikungunya virus infection. Clin Microbiol Infect. 2009; 15(9):880-4. DOI: 10.1111/j.1469-0691.2009.02851.x. View

Tournebize P, Charlin C, LaGrange M . [Neurological manifestations in Chikungunya: about 23 cases collected in Reunion Island]. Rev Neurol (Paris). 2008; 165(1):48-51. DOI: 10.1016/j.neurol.2008.06.009. View

10.

Volk S, Chen R, Tsetsarkin K, Adams A, Garcia T, Sall A . Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary rates. J Virol. 2010; 84(13):6497-504. PMC: 2903258. DOI: 10.1128/JVI.01603-09. View

11.

Mahendradas P, Ranganna S, Shetty R, Balu R, Narayana K, Babu R . Ocular manifestations associated with chikungunya. Ophthalmology. 2007; 115(2):287-91. DOI: 10.1016/j.ophtha.2007.03.085. View

12.

Ernould S, Walters H, Alessandri J, Llanas B, Jaffar M, Robin S . [Chikungunya in paediatrics: epidemic of 2005-2006 in Saint-Denis, Reunion Island]. Arch Pediatr. 2008; 15(3):253-62. DOI: 10.1016/j.arcped.2007.10.019. View

13.

Hoarau J, Bandjee M, Krejbich Trotot P, Das T, Li-Pat-Yuen G, Dassa B . Persistent chronic inflammation and infection by Chikungunya arthritogenic alphavirus in spite of a robust host immune response. J Immunol. 2010; 184(10):5914-27. DOI: 10.4049/jimmunol.0900255. View

14.

Borgherini G, Poubeau P, Staikowsky F, Lory M, Le Moullec N, Becquart J . Outbreak of chikungunya on Reunion Island: early clinical and laboratory features in 157 adult patients. Clin Infect Dis. 2007; 44(11):1401-7. DOI: 10.1086/517537. View

15.

Chopra A, Anuradha V, Lagoo-Joshi V, Kunjir V, Salvi S, Saluja M . Chikungunya virus aches and pains: an emerging challenge. Arthritis Rheum. 2008; 58(9):2921-2. DOI: 10.1002/art.23753. View

16.

Queyriaux B, Simon F, Grandadam M, Michel R, Tolou H, Boutin J . Clinical burden of chikungunya virus infection. Lancet Infect Dis. 2007; 8(1):2-3. DOI: 10.1016/S1473-3099(07)70294-3. View

17.

Couderc T, Khandoudi N, Grandadam M, Visse C, Gangneux N, Bagot S . Prophylaxis and therapy for Chikungunya virus infection. J Infect Dis. 2009; 200(4):516-23. PMC: 7109959. DOI: 10.1086/600381. View

18.

de Lamballerie X, Leroy E, Charrel R, Ttsetsarkin K, Higgs S, Gould E . Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come?. Virol J. 2008; 5:33. PMC: 2266737. DOI: 10.1186/1743-422X-5-33. View

19.

Santhosh S, Dash P, Parida M, Khan M, Tiwari M, Lakshmana Rao P . Comparative full genome analysis revealed E1: A226V shift in 2007 Indian Chikungunya virus isolates. Virus Res. 2008; 135(1):36-41. DOI: 10.1016/j.virusres.2008.02.004. View

20.

Vazeille M, Moutailler S, Coudrier D, Rousseaux C, Khun H, Huerre M . Two Chikungunya isolates from the outbreak of La Reunion (Indian Ocean) exhibit different patterns of infection in the mosquito, Aedes albopictus. PLoS One. 2007; 2(11):e1168. PMC: 2064959. DOI: 10.1371/journal.pone.0001168. View