Differential Transformation Capacity of Src Family Kinases During the Initiation of Prostate Cancer

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2011 Apr 6

PMID 21464326

Citations 56

Authors

Houjian Cai

Daniel A Smith

Sanaz Memarzadeh

Clifford A Lowell

Jonathan A Cooper

Owen N Witte

Affiliations

Soon will be listed here.

Abstract

Src family kinases (SFKs) are pleiotropic activators that are responsible for integrating signal transduction for multiple receptors that regulate cellular proliferation, invasion, and metastasis in a variety of human cancers. Independent groups have identified increased expression of individual SFK members during prostate cancer progression, raising the question of whether SFKs display functional equivalence. Here, we show that Src kinase, followed by Fyn kinase and then Lyn kinase, exhibit ranked tumorigenic potential during both paracrine-induced and cell-autonomous-initiated prostate cancer. This quantitative variation in transformation potential appears to be regulated in part by posttranslational palmitoylation. Our data indicate that development of inhibitors against specific SFK members could provide unique targeted therapeutic strategies.

Citing Articles

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Inhibition of N-myristoyltransferase activity promotes androgen receptor degradation in prostate cancer.

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Palmitoyl acyltransferase ZDHHC7 inhibits androgen receptor and suppresses prostate cancer.

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