The Effect of Both a Thoracic Trauma and a Soft-tissue Trauma on Fracture Healing in a Rat Model

Overview

Journal Acta Orthop

Specialty Orthopedics

Date 2011 Apr 6

PMID 21463222

Citations 15

Authors

Lutz Claes

Anita Ignatius

Raimund Lechner

Florian Gebhard

Michael Kraus

Stefan Baumgartel

Stefan Recknagel

Gert D Krischak

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: There is some clinical evidence that fracture healing is impaired in multiply injured patients. Nothing is known, however, about the effects of various types of injuries and their contribution to a possible disturbance of the fracture-healing process. We investigated the effect of a thoracic trauma and an additional soft-tissue trauma on fracture healing in a rat tibia model.

Methods: 3 groups of rats were operated: group A with a simple fracture of the tibia and fibula, group B with a fracture and an additional thoracic trauma, and group C with a fracture, thoracic trauma, and an additional soft-tissue trauma. The fracture and the soft-tissue injury were produced by a special guillotine-like device and the thoracic trauma by a blast wave generator. After one day, the serum level of IL-6 was quantified, and at the end of the study (28 days) the mechanical properties and the callus volume of the healed tibia were determined.

Results: Increasing the severity of the injury caused IL-6 levels to more than double 1 day after injury. It halved the load to failure in mechanical tests and led to reduced callus volume after 28 days of healing.

Interpretation: Fracture healing is impaired when additional thoracic trauma and soft tissue trauma occurs.

Citing Articles

Polytrauma impairs fracture healing accompanied by increased persistence of innate inflammatory stimuli and reduced adaptive response.

Saiz A, Rahmati M, Gresham R, Baldini T, Burgan J, Lee M J Orthop Res. 2024; 43(3):603-616.

PMID: 39550711 PMC: 11806648. DOI: 10.1002/jor.26015.

Stem Cells and Acellular Preparations in Bone Regeneration/Fracture Healing: Current Therapies and Future Directions.

Brown M, Brady D, Healy K, Henry K, Ogunsola A, Ma X Cells. 2024; 13(12.

PMID: 38920674 PMC: 11201612. DOI: 10.3390/cells13121045.

Influence of Thoracic Trauma on Fracture Healing in Long Bones-A Retrospective Analysis.

Timm K, Walter N, Heinrich M, Knapp G, Thormann U, Khassawna T J Clin Med. 2022; 11(3).

PMID: 35160169 PMC: 8837065. DOI: 10.3390/jcm11030717.

Intact Glucocorticoid Receptor Dimerization Is Deleterious in Trauma-Induced Impaired Fracture Healing.

Hachemi Y, Rapp A, Lee S, Dorn A, Kruger B, Kaiser K Front Immunol. 2021; 11:628287.

PMID: 33679723 PMC: 7927427. DOI: 10.3389/fimmu.2020.628287.

Fracture fixation strategy and specific muscle tissue availability of neutrophilic granulocytes following mono- and polytrauma: intramedullary nailing vs. external fixation of femoral fractures.

Greven J, Horst K, Qiao Z, Blasius F, Mert U, Teuben M Eur J Med Res. 2020; 25(1):62.

PMID: 33243279 PMC: 7689960. DOI: 10.1186/s40001-020-00461-y.

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