Caspase 8 and Caspase 9 Gene Polymorphisms and Susceptibility to Gastric Cancer

Overview

Journal Gastric Cancer

Specialties Gastroenterology
Oncology

Date 2011 Apr 5

PMID 21461653

Citations 15

Authors

Emmanouil Liamarkopoulos

Maria Gazouli

Gerasimos Aravantinos

Nikolaos Tzanakis

George Theodoropoulos

Spyros Rizos

Nikolaos Nikiteas

Affiliations

Soon will be listed here.

Abstract

Background: Caspase-8 (CASP8) and caspase-9 (CASP9) play crucial roles in regulating apoptosis, and their functional polymorphisms may alter cancer risk. Our aim was to investigate the association of CASP8 and CASP9 gene polymorphisms with gastric cancer (GC) susceptibility.

Methods: We undertook a case-control study of 88 GC cases and 480 controls to investigate the association between CASP8 -652 6N ins/del and CASP9 -1263 A>G polymorphisms and GC susceptibility by a polymerase chain reaction (PCR)-restriction fragment length polymorphism method.

Results: CASP8 -652 6N ins/del polymorphism and CASP9 -1263 GG genotype were observed to be significantly associated with a reduced risk of GC. No significant association was observed between CASP8 -652 6N ins/del and CASP9 -1263 A>G polymorphisms and tumor characteristics. However, both CASP8 del/del and CASP9 -1263 GG genotypes were associated with increased overall survival in GC patients.

Conclusions: The CASP8 -652 6N ins/del and the CASP9 -1263 A>G polymorphisms were observed to play a protective role in GC predisposition.

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