Doxycycline for Malaria Chemoprophylaxis and Treatment: Report from the CDC Expert Meeting on Malaria Chemoprophylaxis

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2011 Apr 5

PMID 21460003

Citations 76

Authors

Kathrine R Tan

Alan J Magill

Monica E Parise

Paul M Arguin

Affiliations

Soon will be listed here.

Abstract

Doxycycline, a synthetically derived tetracycline, is a partially efficacious causal prophylactic (liver stage of Plasmodium) drug and a slow acting blood schizontocidal agent highly effective for the prevention of malaria. When used in conjunction with a fast acting schizontocidal agent, it is also highly effective for malaria treatment. Doxycycline is especially useful as a prophylaxis in areas with chloroquine and multidrug-resistant Plasmodium falciparum malaria. Although not recommended for pregnant women and children < 8 years of age, severe adverse events are rarely reported for doxycycline. This report examines the evidence behind current recommendations for the use of doxycycline for malaria and summarizes the available literature on its safety and tolerability.

Citing Articles

"Pleiotropic" Effects of Antibiotics: New Modulators in Human Diseases.

Airola C, Severino A, Spinelli I, Gasbarrini A, Cammarota G, Ianiro G Antibiotics (Basel). 2025; 13(12.

PMID: 39766566 PMC: 11727521. DOI: 10.3390/antibiotics13121176.

To quest new targets of parasite and their potential inhibitors to combat antimalarial drug resistance.

Biswas P, Roy R, Ghosh K, Nath D, Samadder A, Nandi S J Parasit Dis. 2024; 48(4):671-722.

PMID: 39493470 PMC: 11527868. DOI: 10.1007/s12639-024-01687-x.

Doxycycline Post-Exposure Prophylaxis for Bacterial Sexually Transmitted Infections: The Current Landscape and Future Directions.

Allan-Blitz L, Mayer K Curr HIV/AIDS Rep. 2024; 22(1):1.

PMID: 39476167 DOI: 10.1007/s11904-024-00709-w.

Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies.

Carneiro B, Prado M, Nogueira I, Moreira A, Andre C Odontology. 2024; 113(1):15-41.

PMID: 39133374 DOI: 10.1007/s10266-024-00986-2.

Guarding Health: A Comprehensive Review of Nosocomial Infections in Sickle Cell Anemia, a Multifaceted Approach to Prevention.

Batra N, Acharya S, Ahuja A, Saboo K Cureus. 2024; 16(1):e53224.

PMID: 38425631 PMC: 10902742. DOI: 10.7759/cureus.53224.

References

Dotevall L, Hagberg L . Adverse effects of minocycline versus doxycycline in the treatment of Lyme neuroborreliosis. Clin Infect Dis. 2000; 30(2):410-1. DOI: 10.1086/313674. View

Vassileva S, Mateev G, Parish L . Antimicrobial photosensitive reactions. Arch Intern Med. 1998; 158(18):1993-2000. DOI: 10.1001/archinte.158.18.1993. View

Shamiss A, Atar E, Zohar L, Cain Y . Mefloquine versus doxycycline for malaria prophylaxis in intermittent exposure of Israeli Air Force aircrew in Rwanda. Aviat Space Environ Med. 1996; 67(9):872-3. View

Shanks G, Roessler P, Edstein M, Rieckmann K . Doxycycline for malaria prophylaxis in Australian soldiers deployed to United Nations missions in Somalia and Cambodia. Mil Med. 1995; 160(9):443-5. View

Delaney T, Leppard B, Macdonald D . Effects of long term treatment with tetracycline. Acta Derm Venereol. 1974; 54(6):487-9. View

Gonzalez E, Gonzalez S . Drug photosensitivity, idiopathic photodermatoses, and sunscreens. J Am Acad Dermatol. 1996; 35(6):871-85; quiz 886-7. DOI: 10.1016/s0190-9622(96)90108-5. View

Wein S, Maynadier M, Van Ba C, Cerdan R, Peyrottes S, Fraisse L . Reliability of antimalarial sensitivity tests depends on drug mechanisms of action. J Clin Microbiol. 2010; 48(5):1651-60. PMC: 2863886. DOI: 10.1128/JCM.02250-09. View

Sanchez J, DeFraites R, Sharp T, Hanson R . Mefloquine or doxycycline prophylaxis in US troops in Somalia. Lancet. 1993; 341(8851):1021-2. DOI: 10.1016/0140-6736(93)91107-w. View

Winn B, Liao Y, Horton J . Intracranial pressure returns to normal about a month after stopping tetracycline antibiotics. Arch Ophthalmol. 2007; 125(8):1137-8. DOI: 10.1001/archopht.125.8.1137. View

10.

Yeo A, Edstein M, Shanks G, Rieckmann K . Potentiation of the antimalarial activity of atovaquone by doxycycline against Plasmodium falciparum in vitro. Parasitol Res. 1997; 83(5):489-91. DOI: 10.1007/s004360050285. View

11.

Deppermann K, Lode H, Hoffken G, Tschink G, Kalz C, Koeppe P . Influence of ranitidine, pirenzepine, and aluminum magnesium hydroxide on the bioavailability of various antibiotics, including amoxicillin, cephalexin, doxycycline, and amoxicillin-clavulanic acid. Antimicrob Agents Chemother. 1989; 33(11):1901-7. PMC: 172785. DOI: 10.1128/AAC.33.11.1901. View

12.

. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001; 108(3):776-89. DOI: 10.1542/peds.108.3.776. View

13.

Loo W, Kirtschig G, Wojnarowska F . Minocycline as a therapeutic option in bullous pemphigoid. Clin Exp Dermatol. 2001; 26(5):376-9. DOI: 10.1046/j.1365-2230.2001.00838.x. View

14.

Pradines B, Spiegel A, Rogier C, Tall A, Mosnier J, Fusai T . Antibiotics for prophylaxis of Plasmodium falciparum infections: in vitro activity of doxycycline against Senegalese isolates. Am J Trop Med Hyg. 2000; 62(1):82-5. DOI: 10.4269/ajtmh.2000.62.82. View

15.

Schlagenhauf P, Tschopp A, Johnson R, Nothdurft H, Beck B, Schwartz E . Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study. BMJ. 2003; 327(7423):1078. PMC: 261741. DOI: 10.1136/bmj.327.7423.1078. View

16.

GROSSMAN E, Walchek A, FREEDMAN H . Tetracyclines and permanent teeth: the relation between dose and tooth color. Pediatrics. 1971; 47(3):567-70. View

17.

Purvis J, Edwards M . Doxycycline use for rickettsial disease in pediatric patients. Pediatr Infect Dis J. 2000; 19(9):871-4. DOI: 10.1097/00006454-200009000-00011. View

18.

Bryan J . Cost considerations of malaria chemoprophylaxis including use of primaquine for primary or terminal chemoprophylaxis. Am J Trop Med Hyg. 2006; 75(3):416-20. View

19.

Colwell E, HICKMAN R, Intraprasert R, Tirabutana C . Minocycline and tetracycline treatment of acute falciparum malaria in Thailand. Am J Trop Med Hyg. 1972; 21(2):144-9. DOI: 10.4269/ajtmh.1972.21.144. View

20.

Lochary M, Lockhart P, Williams Jr W . Doxycycline and staining of permanent teeth. Pediatr Infect Dis J. 1998; 17(5):429-31. DOI: 10.1097/00006454-199805000-00019. View