Cytotoxic Metabolites from the Soil-derived Fungus Exophiala Pisciphila

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2011 Apr 2

PMID 21455093

Citations 2

Authors

Cui-Cui Wang

Hai-Zhou Liu

Ming Liu

Yu-Yan Zhang

Tian-Tian Li

Xiu-Kun Lin

Affiliations

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Abstract

A new polyketide compound 1 and a new naturally occurring chromone derivative 2, along with two known indole alkaloids 3-4 were characterized from the ethyl acetate extract of a soil-derived fungal strain, Exophiala pisciphila PHF-9. The structures of compounds 1-4 were established by detailed spectroscopic analysis and comparison with literature data. The absolute configuration of 1 was determined by a modified Mosher's method. Compound 1 exhibited moderate cytotoxicity against A-549, Hela, PANC-28 and BEL-7402 cell lines.

Citing Articles

The Novel Compounds with Biological Activity Derived from Soil Fungi in the Past Decade.

Zhang D, Li S, Fan M, Zhao C Drug Des Devel Ther. 2022; 16:3493-3555.

PMID: 36248243 PMC: 9553542. DOI: 10.2147/DDDT.S377921.

Fungal Indicators of Sensitivity and Resistance to Long-Term Maize Monoculture: A Culture-Independent Approach.

Wolinska A, Podlewski J, Slomczewski A, Grzadziel J, Galazka A, Kuzniar A Front Microbiol. 2022; 12:799378.

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