Mlakic M, cadez T, Sinko G, Skoric I, Kovarik Z
Biomolecules. 2024; 14(6).
PMID: 38927082
PMC: 11201660.
DOI: 10.3390/biom14060679.
Wei Z, Zhang D, Liu X, Nie H, OuYang Q, Zhang X
RSC Med Chem. 2024; 15(4):1225-1235.
PMID: 38665821
PMC: 11042241.
DOI: 10.1039/d3md00628j.
Prchalova E, Kohoutova Z, Knittelova K, Malinak D, Musilek K
Arch Toxicol. 2023; 97(11):2839-2860.
PMID: 37642747
DOI: 10.1007/s00204-023-03587-0.
Norrrahim M, Razak M, Ahmad Shah N, Kasim H, Wan Yusoff W, Halim N
RSC Adv. 2022; 10(8):4465-4489.
PMID: 35495228
PMC: 9049292.
DOI: 10.1039/c9ra08599h.
Lindgren C, Forsgren N, Hoster N, Akfur C, Artursson E, Edvinsson L
Chemistry. 2022; 28(40):e202200678.
PMID: 35420233
PMC: 9400889.
DOI: 10.1002/chem.202200678.
A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.
Da Silva O, Probst N, Landry C, Hanak A, Warnault P, Coisne C
J Med Chem. 2022; 65(6):4649-4666.
PMID: 35255209
PMC: 8958973.
DOI: 10.1021/acs.jmedchem.1c01748.
Discovery of Novel Non-Oxime Reactivators Showing In Vivo Antidotal Efficiency for Sarin Poisoned Mice.
Wei Z, Zhang X, Nie H, Yao L, Liu Y, Zheng Z
Molecules. 2022; 27(3).
PMID: 35164361
PMC: 8840479.
DOI: 10.3390/molecules27031096.
Molecular modeling-guided optimization of acetylcholinesterase reactivators: A proof for reactivation of covalently inhibited targets.
Wei Z, Yang J, Liu Y, Nie H, Yao L, Yang J
Eur J Med Chem. 2021; 215:113286.
PMID: 33611189
PMC: 7877871.
DOI: 10.1016/j.ejmech.2021.113286.
Counteracting poisoning with chemical warfare nerve agents.
Macek Hrvat N, Kovarik Z
Arh Hig Rada Toksikol. 2021; 71(4):266-284.
PMID: 33410774
PMC: 7968514.
DOI: 10.2478/aiht-2020-71-3459.
Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes.
Chambers J, Dail M, Meek E
Neuropharmacology. 2020; 175:108201.
PMID: 32544483
PMC: 7492440.
DOI: 10.1016/j.neuropharm.2020.108201.
Organophosphorus compounds and oximes: a critical review.
Worek F, Thiermann H, Wille T
Arch Toxicol. 2020; 94(7):2275-2292.
PMID: 32506210
PMC: 7367912.
DOI: 10.1007/s00204-020-02797-0.
Central neuroprotection demonstrated by novel oxime countermeasures to nerve agent surrogates.
Chambers J, Meek E
Ann N Y Acad Sci. 2020; 1479(1):5-12.
PMID: 32319115
PMC: 9513985.
DOI: 10.1111/nyas.14352.
Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases.
Macek Hrvat N, Kalisiak J, Sinko G, Radic Z, Sharpless K, Taylor P
Toxicol Lett. 2019; 321:83-89.
PMID: 31863869
PMC: 7053431.
DOI: 10.1016/j.toxlet.2019.12.016.
Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study.
Malinak D, Nepovimova E, Jun D, Musilek K, Kuca K
Molecules. 2018; 23(9).
PMID: 30205495
PMC: 6225275.
DOI: 10.3390/molecules23092291.
Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.
Sit R, Kovarik Z, Macek Hrvat N, Zunec S, Green C, Fokin V
J Pharmacol Exp Ther. 2018; 367(2):363-372.
PMID: 30190337
PMC: 6223194.
DOI: 10.1124/jpet.118.249383.
Hydrolysis of DFP and the nerve agent (S)-sarin by DFPase proceeds along two different reaction pathways: implications for engineering bioscavengers.
Wymore T, Field M, Langan P, Smith J, Parks J
J Phys Chem B. 2014; 118(17):4479-89.
PMID: 24720808
PMC: 4010294.
DOI: 10.1021/jp410422c.
In silico studies in probing the role of kinetic and structural effects of different drugs for the reactivation of tabun-inhibited AChE.
Lo R, Chandar N, Kesharwani M, Jain A, Ganguly B
PLoS One. 2013; 8(12):e79591.
PMID: 24312449
PMC: 3846473.
DOI: 10.1371/journal.pone.0079591.
Kinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agents.
Topczewski J, Quinn D
Org Lett. 2013; 15(5):1084-7.
PMID: 23410111
PMC: 3685722.
DOI: 10.1021/ol400054m.
Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.
Radic Z, Sit R, Garcia E, Zhang L, Berend S, Kovarik Z
Chem Biol Interact. 2012; 203(1):67-71.
PMID: 22975155
PMC: 3561488.
DOI: 10.1016/j.cbi.2012.08.014.
Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.
Kovarik Z, Macek N, Sit R, Radic Z, Fokin V, Sharpless K
Chem Biol Interact. 2012; 203(1):77-80.
PMID: 22960624
PMC: 3530643.
DOI: 10.1016/j.cbi.2012.08.019.