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First Efficient Uncharged Reactivators for the Dephosphylation of Poisoned Human Acetylcholinesterase

Overview
Specialty Chemistry
Date 2011 Apr 1
PMID 21451868
Citations 21
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Abstract

Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLö-7.

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