Lower Serum Level of Adiponectin is Associated with Increased Risk of Endoscopic Erosive Gastritis

Overview

Journal Dig Dis Sci

Specialty Gastroenterology

Date 2011 Mar 31

PMID 21448696

Citations 10

Authors

Shunsuke Yamamoto

Kenji Watabe

Shusaku Tsutsui

Shinichi Kiso

Toshimitsu Hamasaki

Motohiko Kato

Yoshihiro Kamada

Yuichi Yoshida

Shinji Kihara

Miyuki Umeda

Aiko Furubayashi

Kazuo Kinoshita

Osamu Kishida

Takashi Fujimoto

Akira Yamada

Yoshifumi Tsukamoto

Norio Hayashi

Yuji Matsuzawa

Affiliations

Soon will be listed here.

Abstract

Background: Obesity is recently known as a risk factor for endoscopic gastritis. Adiponectin is an anti-inflammatory cytokine secreted from fat tissue, and its serum concentrations are reduced in obesity. The relation between adiponectin and gastritis remains unclear.

Aims: The aim of this study was to determine whether lower serum adiponectin level is associated with the risk of endoscopic gastritis.

Methods: We analyzed medical records of participants of a routine health check-up examination. Association among endoscopic findings, serum adiponectin level, and other clinical factors including age, sex, alcohol habit, smoking habit, body mass index (BMI), blood pressure, cholesterol, triglyceride, glucose, and insulin were investigated. Endoscopic erosive gastritis was defined as a flat or minimally depressed white spot surrounded by a reddish area or small elevation with central umbilications mimicking octopus' suckers.

Results: A total of 2,400 participants were enrolled. BMI was significantly higher in gastritis-positive participants than in gastritis-negative participants. Serum adiponectin levels were significantly lower in gastritis-positive participants than in gastritis-negative participants. Multivariate logistic regression analysis revealed that lower serum adiponectin level (OR 0.96; 95% CI 0.93-0.99), smoking (OR 0.50; 95% CI 0.30-0.80), higher blood pressure (OR 1.02; 95% CI 1.01-1.03), and duodenitis (OR 1.8; 95% CI 1.00-3.09) were significantly associated with endoscopic erosive gastritis.

Conclusions: Lower serum level of adiponectin may increase the risk of endoscopic erosive gastritis, independently of BMI. Our findings facilitate further study to clarify the role of hypoadiponectinemia in erosive gastritis.

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