Physiology of the Gonadotrophin-releasing Hormone (GnRH) Neurone: Studies from Embryonic GnRH Neurones

Overview

Journal J Neuroendocrinol

Specialty Endocrinology

Date 2011 Mar 30

PMID 21443528

Citations 17

Authors

S Constantin

Affiliations

Soon will be listed here.

Abstract

Gonadotrophin-releasing hormone (GnRH)-secreting neurones are the final output of the central nervous system driving fertility in all mammals. Although it has been known for decades that the efficiency of communication between the hypothalamus and the pituitary depends on the pulsatile profile of GnRH secretion, how GnRH neuronal activity is patterned to generate pulses at the median eminence is unknown. To date, the scattered distribution of the GnRH cell bodies remains the main limitation to assessing the cellular events that could lead to pulsatile GnRH secretion. Taking advantage of the unique developmental feature of GnRH neurones, the nasal explant model allows primary GnRH neurones to be maintained within a micro-network where pulsatile secretion is preserved and where individual cellular activity can be monitored simultaneously across the cell population. This review summarises the data obtained from work using this in vitro model, and brings some insights into GnRH cellular physiology.

Citing Articles

Sex-Dependent Changes in Gonadotropin-Releasing Hormone Neuron Voltage-Gated Potassium Currents in a Mouse Model of Temporal Lobe Epilepsy.

Rajan R, Christian-Hinman C eNeuro. 2024; 11(10).

PMID: 39375030 PMC: 11493494. DOI: 10.1523/ENEURO.0324-24.2024.

Vasoactive intestinal peptide excites GnRH neurons via KCa3.1, a potential player in the slow afterhyperpolarization current.

Constantin S, Quignon C, Pizano K, Shostak D, Wray S Front Cell Neurosci. 2024; 18:1354095.

PMID: 38633445 PMC: 11021707. DOI: 10.3389/fncel.2024.1354095.

Current Insights in Prolactin Signaling and Ovulatory Function.

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Postnatal Development and Maintenance of Functional Pituitary Gonadotrophs Is Dependent on PI4-Kinase A.

Constantin S, Sokanovic S, Mochimaru Y, Smiljanic K, Sivcev S, Previde R Endocrinology. 2023; 164(12).

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mutation in humans with pubertal failure alters GnRH transcript expression.

Cho H, Gurbuz F, Stamou M, Kotan L, Farmer S, Can S Front Endocrinol (Lausanne). 2023; 14:1203542.

PMID: 37600690 PMC: 10436210. DOI: 10.3389/fendo.2023.1203542.

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