Interplay Between FOXO, TOR, and Akt

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2011 Mar 29

PMID 21440577

Citations 159

Authors

Nissim Hay

Affiliations

Soon will be listed here.

Abstract

FOXO transcription factors have emerged as rheostats that coordinate the activities of Akt and targets of rapamycin complexes (TORCs). This review summarizes the regulatory circuits mediated by the activation of FOXO, which in turn modulate Akt and TORCs activities. The biological significance of these regulatory circuits is discussed in this article. This article is part of a Special Issue entitled: P13K-AKT-FoxO axis in cancer and aging.

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