Individual and Joint Action of Environmental Factors and Risk of MS

Overview

Journal Neurol Clin

Specialty Neurology

Date 2011 Mar 29

PMID 21439439

Citations 22

Authors

I A F van der Mei

S Simpson Jr

J Stankovich

B V Taylor

Affiliations

Soon will be listed here.

Abstract

In this review, the evidence for the leading environmental and lifestyle factors thought to play a role in multiple sclerosis (MS) onset, including Epstein-Barr virus, sun exposure or vitamin D, and smoking, will be discussed. The Causal Pie Model is used as a conceptual framework to understand the causation. Given that no single factor leads to the development of MS, the joint action or interaction of these factors, along with genetic factors, most particularly the HLA-DR15*1501 genotype, is a primary focus.

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