Exploring Airway Diseases by NMR-based Metabonomics: a Review of Application to Exhaled Breath Condensate

Overview

Journal J Biomed Biotechnol

Specialty Biology

Date 2011 Mar 26

PMID 21437214

Citations 15

Authors

Matteo Sofia

Mauro Maniscalco

Guglielmo de Laurentiis

Debora Paris

Dominique Melck

Andrea Motta

Affiliations

Soon will be listed here.

Abstract

There is increasing evidence that biomarkers of exhaled gases or exhaled breath condensate (EBC) may help in detecting abnormalities in respiratory diseases mirroring increased, oxidative stress, airways inflammation and endothelial dysfunction. Beside the traditional techniques to investigate biomarker profiles, "omics" sciences have raised interest in the clinical field as potentially improving disease phenotyping. In particular, metabonomics appears to be an important tool to gain qualitative and quantitative information on low-molecular weight metabolites present in cells, tissues, and fluids. Here, we review the potential use of EBC as a suitable matrix for metabonomic studies using nuclear magnetic resonance (NMR) spectroscopy. By using this approach in airway diseases, it is now possible to separate specific EBC profiles, with implication in disease phenotyping and personalized therapy.

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