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Insulin Glulisine in the Management of Diabetes

Overview
Publisher Dove Medical Press
Specialty Endocrinology
Date 2011 Mar 26
PMID 21437124
Citations 2
Authors
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Abstract

Insulin glulisine is appealing in principle, but the advantages of this drug over the other rapid-acting insulin analogs are still relatively unknown. The frequency of hypoglycemia, convenience in the timing of administration, and improvements in terms of HbA(1c) seem similar among the rapid-acting insulin analogs, including insulin glulisine. Only properly randomized long-term clinical studies with insulin glulisine will reveal the true value of this novel insulin analog.

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References
1.
Nathan D, Genuth S, Lachin J, Cleary P, Crofford O, Davis M . The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993; 329(14):977-86. DOI: 10.1056/NEJM199309303291401. View

2.
Horvath K, Bock G, Regittnig W, Bodenlenz M, Wutte A, Plank J . Insulin glulisine, insulin lispro and regular human insulin show comparable end-organ metabolic effects: an exploratory study. Diabetes Obes Metab. 2007; 10(6):484-91. DOI: 10.1111/j.1463-1326.2007.00734.x. View

3.
. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet. 1998; 352(9131):837-53. View

4.
Becker R . Insulin glulisine complementing basal insulins: a review of structure and activity. Diabetes Technol Ther. 2007; 9(1):109-21. DOI: 10.1089/dia.2006.0035. View

5.
Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven P . Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2008; 360(2):129-39. DOI: 10.1056/NEJMoa0808431. View