Class IIa HDACs: from Important Roles in Differentiation to Possible Implications in Tumourigenesis

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2011 Mar 26

PMID 21435179

Citations 49

Authors

Andrea Clocchiatti

Cristina Florean

Claudio Brancolini

Affiliations

Soon will be listed here.

Abstract

Histone deacetylases (HDACs) are important regulators of gene expression. Specific structural features and distinct regulative mechanisms rationalize the separation of the 18 different human HDACs into four classes. The class II comprises a heterogeneous group of nuclear and cytosolic HDACs involved in the regulation of several cellular functions, not just limited to transcriptional repression. In particular, HDAC4, 5, 7 and 9 belong to the subclass IIa and share many transcriptional partners, including members of the MEF2 family. Genetic studies in mice have disclosed the fundamental contribution of class IIa HDACs to specific developmental/differentiation pathways. In this review, we discuss about the recent literature, which hints a role of class IIa HDACs in the development, growth and aggressiveness of cancer cells.

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