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Nickel-catalyzed Reductive Cross-coupling of Unactivated Alkyl Halides

Overview
Journal Org Lett
Specialties Biochemistry
Chemistry
Date 2011 Mar 26
PMID 21434609
Citations 47
Authors
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Abstract

A Ni-catalyzed reductive approach to the cross-coupling of two unactivated alkyl halides has been successfully developed. The reaction works efficiently for primary and secondary halides, with at least one being bromide. The mild reaction conditions allow for excellent functional group tolerance and provide the C(sp(3))-C(sp(3)) coupling products in moderate to excellent yields.

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