Chlamydia Trachomatis and Placental Inflammation in Early Preterm Delivery

Overview

Journal Eur J Epidemiol

Specialty Public Health

Date 2011 Mar 25

PMID 21431838

Citations 25

Authors

G Ingrid J G Rours

Ronald R de Krijger

Alewijn Ott

Hendrina F M Willemse

Ronald de Groot

Luc J I Zimmermann

Renee F Kornelisse

Henri A Verbrugh

Roel P Verkooijen

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Chlamydia trachomatis may infect the placenta and subsequently lead to preterm delivery. Our aim was to evaluate the relationship between the presence of Chlamydia trachomatis and signs of placental inflammation in women who delivered at 32 weeks gestation or less.

Setting: placental histology and clinical data were prospectively obtained from 304 women and newborns at the Erasmus MC-Sophia, Rotterdam, the Netherlands. C. trachomatis testing of placentas was done retrospectively using PCR. C. trachomatis was detected in 76 (25%) placentas. Histological evidence of placental inflammation was present in 123 (40%) placentas: in 41/76 (54%) placentas with C. trachomatis versus 82/228 (36%) placentas without C. trachomatis infection (OR 2.1, 95% CI 1.2-3.5). C. trachomatis infection correlated with the progression (P = 0.009) and intensity (P = 0.007) of materno-fetal placental inflammation. C. trachomatis DNA was frequently detected in the placenta of women with early preterm delivery, and was associated with histopathological signs of placental inflammation.

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