Vitamin D and Aging: Beyond Calcium and Bone Metabolism

Overview

Journal Maturitas

Specialty Geriatrics

Date 2011 Mar 25

PMID 21429678

Citations 28

Authors

Faustino R Perez-Lopez

Peter Chedraui

Ana M Fernandez-Alonso

Affiliations

Soon will be listed here.

Abstract

Background: Low serum 25-hydroxyvitamin D (25[OH]D) levels are common and may be associated with morbidity and mortality (and indeed with frailty more generally). This association is not restricted to the links between vitamin D and calcium and bone metabolism.

Objective: To review the influences of vitamin D on the aging process other than those related to bone and calcium. Its effect on mortality is also assessed.

Methods: The PubMed database was searched for English-language articles relating to vitamin D, using the following MeSH terms: vitamin D, mortality, cardiovascular diseases, and frailty. In addition, searches were carried out with Google.

Results: Although some of the reported results have proved controversial, overall the evidence seems to support an association between low serum 25[OH]D levels and mortality rates (all-cause and cardiovascular). Frailty is a condition frequently associated with low serum 25[OH]D levels.

Conclusion: The aging process and mortality are associated with low vitamin D levels. Prospective controlled trials are warranted to determine whether vitamin D supplements can increase longevity and reduce the incidence of certain conditions.

Citing Articles

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Effect of vitamin D metabolites on bone histomorphometry in healthy black and white women: An attempt to unravel the so-called vitamin D paradox in blacks.

Qiu S, Divine G, Rao S Bone Rep. 2023; 18:101650.

PMID: 36588780 PMC: 9801084. DOI: 10.1016/j.bonr.2022.101650.