Biological Monitoring of a Xenomaterial for Grafting: an Evaluation in Critical-size Calvarial Defects

Overview

Journal J Mater Sci Mater Med

Publisher Springer

Specialty Biomedical Engineering

Date 2011 Mar 23

PMID 21424598

Citations 5

Authors

Thais Accorsi-Mendonca

Willian Fernando Zambuzzi

Clovis Monteiro Bramante

Tania Mari Cestari

Rumio Taga

Marcia Sader

Gloria Dulce de Almeida Soares

Jose Mauro Granjeiro

Affiliations

Soon will be listed here.

Abstract

Our purpose was to evaluate the osteoconduction potential of mixed bovine bone (MBB) xenografts as an alternative for bone grafting of critical-size defects in the calvaria of rats. After surgery, in the time intervals of 1, 3, 6, and 9 months, rats were killed and their skulls collected, radiographed and histologically prepared for analysis. The data obtained from histological analysis reported that the particles of MBB did not promote an intense immunological response, evidencing its biocompatibility in rats. Our results clearly showed the interesting evidence that MBB was not completely reabsorbed at 9 months while a small amount of newly formed bone was deposited by osteoprogenitor cells bordering the defect. However, this discrete bone-forming stimulation was unable to regenerate the bone defect. Overall, our results suggest that the properties of MBB are not suitable for stimulating intense bone regeneration in critical bone defects in rats.

Citing Articles

Biological evaluation of critical bone defect regeneration using hydroxyapatite/ alginate composite granules.

Ribeiro I, Almeida R, Silva A, Barbosa Junior A, Rossi A, Miguel F Acta Cir Bras. 2024; 39:e392824.

PMID: 39046039 PMC: 11262755. DOI: 10.1590/acb392824.

Evaluation of Guided Bone Regeneration in Critical Defects Using Bovine and Porcine Collagen Membranes: Histomorphometric and Immunohistochemical Analyses.

Ramires G, Helena J, Oliveira J, Faverani L, Bassi A Int J Biomater. 2021; 2021:8828194.

PMID: 33859694 PMC: 8024098. DOI: 10.1155/2021/8828194.

Osteopromotion Capacity of Bovine Cortical Membranes in Critical Defects of Rat Calvaria: Histological and Immunohistochemical Analysis.

Danieletto-Zanna C, Bizelli V, Ramires G, Francatti T, Carvalho P, Bassi A Int J Biomater. 2020; 2020:6426702.

PMID: 32148506 PMC: 7049411. DOI: 10.1155/2020/6426702.

Analysis of bone formation and membrane resorption in guided bone regeneration using deproteinized bovine bone mineral versus calcium sulfate.

Gavazzoni A, Iwaki Filho L, Hernandes L J Mater Sci Mater Med. 2018; 29(11):167.

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The effect of 4-hexylresorcinol on xenograft degradation in a rat calvarial defect model.

Kang Y, Noh J, Lee M, Chae W, Lee S, Kim S Maxillofac Plast Reconstr Surg. 2016; 38(1):29.

PMID: 27547747 PMC: 4974267. DOI: 10.1186/s40902-016-0076-y.

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