Evaluation of Supporting Role of a Foldable Capsular Vitreous Body with Magnetic Resonance Imaging in the Treatment of Severe Retinal Detachment in Human Eyes

Overview

Journal Eye (Lond)

Specialty Ophthalmology

Date 2011 Mar 23

PMID 21423138

Citations 7

Authors

R Zhang

T Wang

C Xie

X Lin

Z Jiang

Z Wang

Y Liu

Y Luo

C Long

L He

P Wang

Q Gao

Affiliations

Soon will be listed here.

Abstract

Purpose: To determine the supporting role of a novel foldable capsular vitreous body (FCVB) with magnetic resonance imaging (MRI) in the treatment of severe retinal detachment in human eyes.

Methods: The study examined nine eyes of nine patients. Among the nine eyes, five had suffered penetrating injuries while four had suffered contusions of the eyeball involving large defects of the retina or choroids. A standard three-port pars plana vitrectomy was performed, FCVB was triple-folded and sent into the vitreous cavity; balanced salt solution (BSS) was injected into the capsule to support the retina. Three cardinal axes of nine eyes were examined using MRI at baseline and at the 3-month follow up.

Results: MRI revealed that the signal intensity of the FCVB was similar to the normal vitreous body, with low-signal intensity on T1-weighted image and high-signal intensity on T2-weighted image. In three pre-operative silicone oil- or heavy silicone oil-filled eyes, FCVBs were not fully inflated, and eyeball deformation was observed in one eye. Shifts of three cardinal axes of three eyes (horizontal, anteroposterior, and vertical) according to MRI, were -4.33, -4.67, and -2.67 mm. In the remaining six eyes, FCVBs were well distributed in the vitreous cavity and evenly supported the retina; the cardinal axes of the eyes were similar to pre-operation. Shifts of three cardinal axes of six eyes were -0.34, -0.34, and -0.34 mm. In a total of nine eyes, shifts of three cardinal axes were -1.67, -1.77, and -1.11 mm. Statistically significant difference showed only between the horizontal axis of nine eyes pre-operatively and post-operatively (P1=0.041, P2=0.058, P3=0.123).

Conclusion: This study demonstrated the effectiveness of MRI to monitor the supporting role of an FCVB in the treatment of severe retinal detachment in human eyes.

Citing Articles

Foldable capsular vitreous body indications, complications, and outcomes: a systematic review.

Abu Serhan H, Irshaidat S, Abu Serhan L, Elnahry A Graefes Arch Clin Exp Ophthalmol. 2023; 261(8):2103-2116.

PMID: 36795160 DOI: 10.1007/s00417-023-05995-5.

Evaluation of Foldable Capsular Vitreous Body Implantation Surgery.

Luo L, Wei Q, Liu Q, Wang L, Jiang Y Int J Gen Med. 2022; 15:7077-7087.

PMID: 36097567 PMC: 9464037. DOI: 10.2147/IJGM.S380609.

Comparison of Viscoelastic Substance Injection Versus Air Filling in the Anterior Chamber During Foldable Capsular Vitreous Body (FCVB) Implant Surgery: A Prospective Randomized Controlled Trial.

Zhang Z, Liu S, Xie F, Jiang B, Sun M, Sun D Adv Ther. 2021; 38(9):4859-4871.

PMID: 34351566 PMC: 8408088. DOI: 10.1007/s12325-021-01840-5.

Foldable capsular vitreous body implantation for treatment of traumatic retinal detachment: two case reports.

Zeng B, Wang Q, Sui G, Wang M, Xie W, Fu J J Int Med Res. 2021; 49(2):300060521990257.

PMID: 33563057 PMC: 7879493. DOI: 10.1177/0300060521990257.

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation.

Zhang X, Tian X, Zhang B, Guo L, Li X, Jia Y BMC Ophthalmol. 2019; 19(1):260.

PMID: 31852464 PMC: 6921415. DOI: 10.1186/s12886-019-1268-x.

References

Lam R, Cheung B, Yuen C, Wong D, Lam D, Lai W . Retinal redetachment after silicone oil removal in proliferative vitreoretinopathy: a prognostic factor analysis. Am J Ophthalmol. 2008; 145(3):527-533. DOI: 10.1016/j.ajo.2007.10.015. View

Colthurst M, Williams R, Hiscott P, Grierson I . Biomaterials used in the posterior segment of the eye. Biomaterials. 2000; 21(7):649-65. DOI: 10.1016/s0142-9612(99)00220-3. View

Cheng H, Singh O, Kwong K, Xiong J, Woods B, Brady T . Shape of the myopic eye as seen with high-resolution magnetic resonance imaging. Optom Vis Sci. 1992; 69(9):698-701. DOI: 10.1097/00006324-199209000-00005. View

Liu Y, Jiang Z, Gao Q, Ge J, Chen J, Cao X . Technical standards of a foldable capsular vitreous body in terms of mechanical, optical, and biocompatible properties. Artif Organs. 2010; 34(10):836-45. DOI: 10.1111/j.1525-1594.2010.01006.x. View

Castellarin A, Grigorian R, Bhagat N, Del Priore L, Zarbin M . Vitrectomy with silicone oil infusion in severe diabetic retinopathy. Br J Ophthalmol. 2003; 87(3):318-21. PMC: 1771528. DOI: 10.1136/bjo.87.3.318. View

Gao Q, Mou S, Ge J, To C, Hui Y, Liu A . A new strategy to replace the natural vitreous by a novel capsular artificial vitreous body with pressure-control valve. Eye (Lond). 2007; 22(3):461-8. DOI: 10.1038/sj.eye.6702875. View

Karel I, Kalvodova B . Long-term results of pars plana vitrectomy and silicone oil for complications of diabetic retinopathy. Eur J Ophthalmol. 1994; 4(1):52-8. DOI: 10.1177/112067219400400109. View

Pastor J . Proliferative vitreoretinopathy: an overview. Surv Ophthalmol. 1998; 43(1):3-18. DOI: 10.1016/s0039-6257(98)00023-x. View

Gao Q, Chen X, Ge J, Liu Y, Jiang Z, Lin Z . Refractive shifts in four selected artificial vitreous substitutes based on Gullstrand-Emsley and Liou-Brennan schematic eyes. Invest Ophthalmol Vis Sci. 2009; 50(7):3529-34. DOI: 10.1167/iovs.08-2802. View

10.

Azen S, Scott I, Flynn Jr H, Lai M, Topping T, Benati L . Silicone oil in the repair of complex retinal detachments. A prospective observational multicenter study. Ophthalmology. 1998; 105(9):1587-97. DOI: 10.1016/S0161-6420(98)99023-6. View

11.

Quiram P, Gonzales C, Hu W, Gupta A, Yoshizumi M, Kreiger A . Outcomes of vitrectomy with inferior retinectomy in patients with recurrent rhegmatogenous retinal detachments and proliferative vitreoretinopathy. Ophthalmology. 2006; 113(11):2041-7. DOI: 10.1016/j.ophtha.2006.05.039. View

12.

Karel I, Michalickova M . Pars plana vitrectomy in the pediatric population: indications and long-term results. Eur J Ophthalmol. 1999; 9(3):231-7. DOI: 10.1177/112067219900900311. View

13.

Soman N, Banerjee R . Artificial vitreous replacements. Biomed Mater Eng. 2003; 13(1):59-74. View

14.

Hong Y, Chirila T, Vijayasekaran S, Shen W, Lou X, Dalton P . Biodegradation in vitro and retention in the rabbit eye of crosslinked poly(1-vinyl-2-pyrrolidinone) hydrogel as a vitreous substitute. J Biomed Mater Res. 1998; 39(4):650-9. DOI: 10.1002/(sici)1097-4636(19980315)39:4<650::aid-jbm21>3.0.co;2-9. View

15.

. Vitrectomy with silicone oil or sulfur hexafluoride gas in eyes with severe proliferative vitreoretinopathy: results of a randomized clinical trial. Silicone Study Report 1. Arch Ophthalmol. 1992; 110(6):770-9. DOI: 10.1001/archopht.1992.01080180042027. View

16.

CIBIS P, Becker B, Okun E, Canaan S . The use of liquid silicone in retinal detachment surgery. Arch Ophthalmol. 1962; 68:590-9. DOI: 10.1001/archopht.1962.00960030594005. View

17.

Liu Y, Ke Q, Chen J, Wang Z, Xie Z, Jiang Z . Sustained mechanical release of dexamethasone sodium phosphate from a foldable capsular vitreous body. Invest Ophthalmol Vis Sci. 2009; 51(3):1636-42. DOI: 10.1167/iovs.09-4134. View

18.

Scott I, Flynn Jr H, Murray T, Smiddy W, Davis J, Feuer W . Outcomes of complex retinal detachment repair using 1000- vs 5000-centistoke silicone oil. Arch Ophthalmol. 2005; 123(4):473-8. DOI: 10.1001/archopht.123.4.473. View

19.

Bhisitkul R, Gonzalez V . "Heavy oil" for intraocular tamponade in retinal detachment surgery. Br J Ophthalmol. 2005; 89(6):649-50. PMC: 1772660. DOI: 10.1136/bjo.2004.057182. View

20.

Mackiewicz J, Muhling B, Hiebl W, Meinert H, Maaijwee K, Kociok N . In vivo retinal tolerance of various heavy silicone oils. Invest Ophthalmol Vis Sci. 2007; 48(4):1873-83. DOI: 10.1167/iovs.06-0941. View