AllerML: Markup Language for Allergens

Overview

Journal Regul Toxicol Pharmacol

Publisher Elsevier

Specialties Pharmacology
Toxicology

Date 2011 Mar 23

PMID 21420460

Citations 5

Authors

Ovidiu Ivanciuc

Steven M Gendel

Trevor D Power

Catherine H Schein

Werner Braun

Affiliations

Soon will be listed here.

Abstract

Many concerns have been raised about the potential allergenicity of novel, recombinant proteins into food crops. Guidelines, proposed by WHO/FAO and EFSA, include the use of bioinformatics screening to assess the risk of potential allergenicity or cross-reactivities of all proteins introduced, for example, to improve nutritional value or promote crop resistance. However, there are no universally accepted standards that can be used to encode data on the biology of allergens to facilitate using data from multiple databases in this screening. Therefore, we developed AllerML a markup language for allergens to assist in the automated exchange of information between databases and in the integration of the bioinformatics tools that are used to investigate allergenicity and cross-reactivity. As proof of concept, AllerML was implemented using the Structural Database of Allergenic Proteins (SDAP; http://fermi.utmb.edu/SDAP/) database. General implementation of AllerML will promote automatic flow of validated data that will aid in allergy research and regulatory analysis.

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