Vitamin D Deficiency in Cirrhosis Relates to Liver Dysfunction Rather Than Aetiology

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2011 Mar 18

PMID 21412501

Citations 57

Authors

Mikkel Malham

Soren Peter Jorgensen

Peter Ott

Jorgen Agnholt

Hendrik Vilstrup

Mette Borre

Jens F Dahlerup

Affiliations

Soon will be listed here.

Abstract

Aim: To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis.

Methods: Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment.

Results: Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (P < 0.001). In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score.

Conclusion: Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis.

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