Genotype of Varicella-zoster Virus Isolates in South Korea

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2011 Mar 18

PMID 21411584

Citations 7

Authors

Kye-Hyung Kim

Young Ju Choi

Kyoung-Ho Song

Wan Beom Park

Jae-Hyun Jeon

Sang-Won Park

Hong Bin Kim

Nam Joong Kim

Myoung-Don Oh

Affiliations

Soon will be listed here.

Abstract

Information about the genotype of varicella-zoster virus (VZV) is useful to monitor outbreaks of vaccine strains. However, in South Korea, where varicella vaccine was introduced in 1988, there are limited data about the genotype of VZV. VZV was isolated from vesicular lesions of patients with herpes zoster or varicella in South Korea between January 2007 and June 2009. DNAs were purified from single-passage isolates. The genotype was determined by sequence analysis of open reading frame (ORF) 22. The PstI restriction enzyme site in ORF 38 and the BglI restriction enzyme site in ORF 54 were evaluated by restriction enzyme analysis. Forty-four patients with herpes zoster and nine patients with varicella were enrolled. The median age of patients with herpes zoster was 59.5 (range, 10 to 77) years, and the median age of patients with varicella was 8 (range, 6 to 9) years. In sequence analysis of ORF 22, all isolates were genotype J, irrespective of the age group. In restriction enzyme analysis, 51 of 54 (94.3%) isolates contained a PstI site in ORF 38, and all isolates contained a BglI site in ORF 54. Our data suggest that genotype J has been circulating since the 1940s in South Korea.

Citing Articles

Genotype of Varicella-zoster virus isolated in Jiangsu, China.

Wang Y, Zhang L, Bian M, Guo H, Wang Z, Hu Y Virol J. 2024; 21(1):264.

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Seroprevalence and molecular characteristics of varicella-zoster virus infection in Chinese children.

Luan L, Shen X, Qiu J, Jing Y, Zhang J, Wang J BMC Infect Dis. 2019; 19(1):643.

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Characterization and phylogenetic analysis of Varicella-zoster virus strains isolated from Korean patients.

Kim M, Jeon J, Kim I, Park J, Park H, Shin O J Microbiol. 2017; 55(8):665-672.

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Differentiation between wild-type and vaccines strains of varicella zoster virus (VZV) based on four single nucleotide polymorphisms.

Jin L, Xu S, Maple P, Xu W, Brown K Epidemiol Infect. 2017; 145(12):2618-2625.

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Nationwide distribution of varicella-zoster virus clades in China.

Xu S, Chen M, Zheng H, Wang H, Chen M, Zhou J BMC Infect Dis. 2016; 16(1):542.

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