Optic Nerve Potentials and Cortical Potentials After Stimulation of the Anterior Visual Pathway During Neurosurgery

Overview

Journal Doc Ophthalmol

Specialty Ophthalmology

Date 2011 Mar 17

PMID 21409432

Citations 5

Authors

Mitja Benedicic

Roman Bosnjak

Affiliations

Soon will be listed here.

Abstract

The aim was to present cortical potentials after intraoperative electrical epidural stimulation of the optic nerve (ON) in individuals with normal preoperative vision. Optic nerve potentials after flash and electrical stimulation were additionally recorded. Contact electrodes on ON and occiput were used for monopolar recording of optic nerve potentials and cortical potentials, respectively. Epidural stimulating electrodes on ON were used to deliver a rectangular current pulse (intensity 0.2-5.0 mA; duration 0.1-0.3 ms; rate 2 Hz), and LED flash goggles were used for flash stimulation. Optic nerve potentials after flash stimulation predominantly consisted of a positive deflection with a latency around 40 ms, followed by a longer-lasting negativity with the peak at around 50 ms. Optic nerve potentials after electrical epidural stimulation of ON were comprised of a negative deflection at around 3 ms. A positive and a negative deflection at 20 and 30 ms, respectively, and a smaller positive deflection at 40 ms constituted cortical potentials after electrical epidural stimulation of ON. Stable and repeatable cortical potentials after electrical epidural stimulation of ON could safely be recorded in humans during neurosurgery. The origin of these presumably far-field potentials and their potential role in intraoperative monitoring remains to be established.

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References

Park C, Jung H, Yang S, Seol H, Paek S, Kim D . Surgically treated tuberculum sellae and diaphragm sellae meningiomas: the importance of short-term visual outcome. Neurosurgery. 2006; 59(2):238-43. DOI: 10.1227/01.NEU.0000223341.08402.C5. View

Pratt H, Bleich N, Martin W . Short latency visual evoked potentials to flashes from light-emitting diodes. Electroencephalogr Clin Neurophysiol. 1995; 96(6):502-8. DOI: 10.1016/0013-4694(95)00089-h. View

JEWETT D, Deupree D, Bommannan D . Far-field potentials generated by action potentials of isolated frog sciatic nerves in a spherical volume. Electroencephalogr Clin Neurophysiol. 1990; 75(2):105-17. DOI: 10.1016/0013-4694(90)90158-g. View

Cedzich C, Schramm J . Monitoring of flash visual evoked potentials during neurosurgical operations. Int Anesthesiol Clin. 1990; 28(3):165-9. DOI: 10.1097/00004311-199002830-00006. View

Nakanishi T . Action potentials recorded by fluid electrodes. Electroencephalogr Clin Neurophysiol. 1982; 53(3):343-5. DOI: 10.1016/0013-4694(82)90095-5. View

Delbeke J, Pins D, Michaux G, Parrini S, Veraart C . Electrical stimulation of anterior visual pathways in retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2001; 42(1):291-7. View

Pratt H, Bleich N, BERLINER E . Short latency visual evoked potentials in man. Electroencephalogr Clin Neurophysiol. 1982; 54(1):55-62. DOI: 10.1016/0013-4694(82)90231-0. View

Suzukawa K . Evaluation of the transcranial approach to pituitary adenomas based on quantitative analysis of pre- and postoperative visual function. Neurol Med Chir (Tokyo). 1989; 29(11):1012-9. DOI: 10.2176/nmc.29.1012. View

Bosnjak R, Benedicic M . Direct epidural electrical stimulation of the optic nerve: a new method for intraoperative assessment of function. J Neurosurg. 2008; 109(4):647-53. DOI: 10.3171/JNS/2008/109/10/0647. View

10.

Kikuchi Y, Sasaki T, Matsumoto M, Oikawa T, Itakura T, Kodama N . Optic nerve evoked potentials elicited by electrical stimulation. Neurol Med Chir (Tokyo). 2005; 45(7):349-55. DOI: 10.2176/nmc.45.349. View

11.

McGill K, Cummins K, Dorfman L, Berlizot B, Leutkemeyer K, Nishimura D . On the nature and elimination of stimulus artifact in nerve signals evoked and recorded using surface electrodes. IEEE Trans Biomed Eng. 1982; 29(2):129-37. DOI: 10.1109/TBME.1982.325019. View

12.

Brelen M, Vince V, Gerard B, Veraart C, Delbeke J . Measurement of evoked potentials after electrical stimulation of the human optic nerve. Invest Ophthalmol Vis Sci. 2010; 51(10):5351-5. DOI: 10.1167/iovs.09-4346. View

13.

Oozeer M, Veraart C, Legat V, Delbeke J . Simulation of intra-orbital optic nerve electrical stimulation. Med Biol Eng Comput. 2006; 43(5):608-17. DOI: 10.1007/BF02351034. View

14.

Parrini S, Delbeke J, Legat V, Veraart C . Modelling analysis of human optic nerve fibre excitation based on experimental data. Med Biol Eng Comput. 2000; 38(4):454-64. DOI: 10.1007/BF02345016. View

15.

Cedzich C, Schramm J, Mengedoht C, Fahlbusch R . Factors that limit the use of flash visual evoked potentials for surgical monitoring. Electroencephalogr Clin Neurophysiol. 1988; 71(2):142-5. DOI: 10.1016/0168-5597(88)90072-x. View

16.

Hawlina M, Konec B . New noncorneal HK-loop electrode for clinical electroretinography. Doc Ophthalmol. 1992; 81(2):253-9. DOI: 10.1007/BF00156014. View

17.

Margalit N, Lesser J, Moche J, Sen C . Meningiomas involving the optic nerve: technical aspects and outcomes for a series of 50 patients. Neurosurgery. 2003; 53(3):523-32; discussion 532-3. DOI: 10.1227/01.neu.0000079506.75164.f4. View

18.

Moller A, Burgess J, Sekhar L . Recording compound action potentials from the optic nerve in man and monkeys. Electroencephalogr Clin Neurophysiol. 1987; 67(6):549-55. DOI: 10.1016/0013-4694(87)90057-5. View

19.

Jallo G, Benjamin V . Tuberculum sellae meningiomas: microsurgical anatomy and surgical technique. Neurosurgery. 2002; 51(6):1432-39; discussion 1439-40. View

20.

Cedzich C, Schramm J, Fahlbusch R . Are flash-evoked visual potentials useful for intraoperative monitoring of visual pathway function?. Neurosurgery. 1987; 21(5):709-15. DOI: 10.1227/00006123-198711000-00018. View