Evaluation of Antifungal Activity of Medicinal Plant Extracts Against Oral Candida Albicans and Proteinases

Overview

Journal Mycopathologia

Specialties Microbiology
Pharmacology

Date 2011 Mar 17

PMID 21409409

Citations 3

Authors

Jose Francisco Hofling

Rita Cassia Mardegan

Paula Cristina Anibal

Vivian Fernandes Furletti

Mary Ann Foglio

Affiliations

Soon will be listed here.

Abstract

Proteinases produced by Candida albicans are one kind of virulence factor expressed that contribute to adherence and invasion of host tissue. Proteinase inhibitor of human immunodeficiency virus in experimental candidiasis suggested reduction in fungal infection, and medicinal plants could be a source of alternative agent to prevent diseases. In this study, we investigated the production of proteinases by C. albicans from clinical isolates and the action of plant extracts against strains of C. albicans and its synthesized proteinases, comparing with antifungal fluconazole and amphotericin B and proteinase inhibitors pepstatin A, amprenavir, and ritonavir. The results reported here showed that these extracts have a certain kind of action and that the search for new antifungal agents could be found at the plants.

Citing Articles

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Bras G, Satala D, Juszczak M, Kulig K, Wronowska E, Bednarek A Int J Mol Sci. 2024; 25(9).

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Resistance to Antibiotics and Antifungal Medicinal Products: Can Complementary and Alternative Medicine Help Solve the Problem in Common Infection Diseases? The Introduction of a Dutch Research Consortium.

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Coriandrum sativum L. (Coriander) essential oil: antifungal activity and mode of action on Candida spp., and molecular targets affected in human whole-genome expression.

Freires I, Murata R, Furletti V, Sartoratto A, de Alencar S, Figueira G PLoS One. 2014; 9(6):e99086.

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