Direct Effects of Phosphate on Vascular Cell Function

Overview

Journal Adv Chronic Kidney Dis

Specialty Nephrology

Date 2011 Mar 17

PMID 21406295

Citations 53

Authors

Wei Ling Lau

Ashwini Pai

Sharon M Moe

Cecilia M Giachelli

Affiliations

Soon will be listed here.

Abstract

Elevated serum phosphate has clinically been associated with vascular stiffness and cardiovascular mortality. Mechanistic studies over the past decade regarding local effects of phosphate on the vessel wall have provided insight into various pathways that culminate in vascular calcification. Smooth muscle cell phenotype change and apoptosis play prominent roles. The sodium-phosphate cotransporter PiT-1 is required for the osteochondrogenic differentiation of smooth muscle cells in vitro. Less is known about phosphate-driven valve interstitial cell calcification and elastin degradation. In this article, we review the current knowledge about phosphate-induced changes in the vascular wall.

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