Comparative Effects of Verapamil, Nicardipine, and Nitroglycerin on Myocardial Ischemia/reperfusion Injury

Overview

Journal Anesthesiol Res Pract

Publisher Wiley

Specialty Anesthesiology

Date 2011 Mar 16

PMID 21403860

Citations 6

Authors

Hitoshi Yui

Uno Imaizumi

Hisashi Beppu

Mitsuhiro Ito

Munetaka Furuya

Hirofumi Arisaka

Kazu-Ichi Yoshida

Affiliations

Soon will be listed here.

Abstract

The aim of this experiment was to establish whether verapamil, nicardipine, and nitroglycerin have (1) infarct size-limiting effects and (2) antiarrhythmic effects in in vivo rabbit hearts during ischemia/reperfusion. Rabbits received regional ischemia by 30 min of left anterior descending coronary artery occlusion followed by 3 hours of reperfusion under ketamine and xylazine anesthesia. The animals were randomly assigned to the following 4 treatment groups: a control group, a verapamil group, a nicardipine group, and a nitroglycerin group. A continuous infusion of verapamil, nicardipine, or nitroglycerin was initiated 5 min prior to ischemia. Infarct size/area at risk decreased in verapamil, and nitroglycerin. The incidence of ischemia-induced arrhythmia decreased in nicardipine, verapamil and nitroglycerin. The incidence of reperfusion-induced arrhythmias decreased in verapamil and nitroglycerin. From the present experimental results, verapamil and nitroglycerin rather than nicardipine did afford significant protection to the heart subjected to ischemia and reperfusion in a rabbit model.

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