Acute Kidney Injury in Patients with Influenza A (H1N1) 2009

Overview

Journal Intensive Care Med

Specialty Critical Care

Date 2011 Mar 12

PMID 21394631

Citations 23

Authors

Ville Pettila

Steven A R Webb

Michael Bailey

Belinda Howe

Ian M Seppelt

Rinaldo Bellomo

Affiliations

Soon will be listed here.

Abstract

Objective: We aim to evaluate the incidence and outcome of acute kidney injury (AKI) among critically ill adult patients with H1N1 2009 infection.

Design And Patients: From a prospectively collected influenza A (H1N1) 2009 bi-national, we identified 671 adult patients admitted to intensive care unit (ICU) from June 1 to August 31, 2009. Of these, 628 (93.6%) had admission and/or peak serum creatinine values during ICU stay. We defined AKI according to the creatinine criteria of the RIFLE classification.

Results: Of 628 adult patients, 211 [33.6%, 95% confidence interval (CI) 29.8-37.4%] had AKI: 41 (6.5%) risk, 56 (8.9%) injury and 114 (18.2%) failure. Of all 211 AKI patients, 76 [36.0% (29.4-42.6%)] died in hospital (36.6% in risk, 25.0% in injury and 41.3% in failure group) compared with 33 of 408 (8.1%) patients without AKI. Among the 33 AKI patients treated with renal replacement therapy, 13 died (39.4%). Mechanical ventilation [odds ratio (OR) 3.62 (2.07-6.34)], any severe co-morbidity (OR 2.36, 95% CI 1.15-3.71), age (OR 1.02, 95% CI 1.01-1.03 per 1 year increase), and AKI (OR 6.69, 95% CI 4.25-10.55) were independently associated with hospital mortality.

Conclusions: Acute kidney injury appears common in H1N1 2009 infected patients and is independently associated with an increased risk of hospital mortality.

Citing Articles

: A Mini-Review of Acute Kidney Injury Related to Acute Respiratory Distress Syndrome in Critically Ill Patients.

Marchiset A, Jamme M Front Nephrol. 2023; 2:877529.

PMID: 37675005 PMC: 10479595. DOI: 10.3389/fneph.2022.877529.

Predictors of mortality in COVID-19 induced acute kidney injury.

Yuksel E, Arac S, Deniz Altintas D Ther Apher Dial. 2022; 26(5):897-907.

PMID: 35691010 PMC: 9347688. DOI: 10.1111/1744-9987.13895.

AKI in Hospitalized Patients with COVID-19 and Seasonal Influenza: A Comparative Analysis.

Bhasin B, Veitla V, Dawson A, Garacci Z, Sturgill D, Ozieh M Kidney360. 2022; 2(4):619-628.

PMID: 35373047 PMC: 8791326. DOI: 10.34067/KID.0007322020.

Incidence and Risk Factors of Acute Kidney Injury in Patients Hospitalized with Pneumonia: A Prospective Observational Study.

Latief M, Ahmed Para R, Shafi O, Hassan Z, Farooq S, Abbas F Med J Islam Repub Iran. 2022; 35:150.

PMID: 35321362 PMC: 8840859. DOI: 10.47176/mjiri.35.150.

Acute Kidney Injury and Renal Replacement Therapy in COVID-19 Versus Other Respiratory Viruses: A Systematic Review and Meta-Analysis.

Cau A, Cheng M, Lee T, Levin A, Lee T, Vinh D Can J Kidney Health Dis. 2021; 8:20543581211052185.

PMID: 34733538 PMC: 8558598. DOI: 10.1177/20543581211052185.

References

Ricci Z, Cruz D, Ronco C . The RIFLE criteria and mortality in acute kidney injury: A systematic review. Kidney Int. 2007; 73(5):538-46. DOI: 10.1038/sj.ki.5002743. View

Vandenbroucke J, von Elm E, Altman D, Gotzsche P, Mulrow C, Pocock S . Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Epidemiology. 2007; 18(6):805-35. DOI: 10.1097/EDE.0b013e3181577511. View

Levey A, Bosch J, Lewis J, Greene T, Rogers N, Roth D . A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med. 1999; 130(6):461-70. DOI: 10.7326/0003-4819-130-6-199903160-00002. View

Bosch X, Poch E, Grau J . Rhabdomyolysis and acute kidney injury. N Engl J Med. 2009; 361(1):62-72. DOI: 10.1056/NEJMra0801327. View

Webb S, Pettila V, Seppelt I, Bellomo R, Bailey M, Cooper D . Critical care services and 2009 H1N1 influenza in Australia and New Zealand. N Engl J Med. 2009; 361(20):1925-34. DOI: 10.1056/NEJMoa0908481. View

Joannidis M, Metnitz B, Bauer P, Schusterschitz N, Moreno R, Druml W . Acute kidney injury in critically ill patients classified by AKIN versus RIFLE using the SAPS 3 database. Intensive Care Med. 2009; 35(10):1692-702. DOI: 10.1007/s00134-009-1530-4. View

Payen D, de Pont A, Sakr Y, Spies C, Reinhart K, Vincent J . A positive fluid balance is associated with a worse outcome in patients with acute renal failure. Crit Care. 2008; 12(3):R74. PMC: 2481469. DOI: 10.1186/cc6916. View

Hoste E, Clermont G, Kersten A, Venkataraman R, Angus D, De Bacquer D . RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care. 2006; 10(3):R73. PMC: 1550961. DOI: 10.1186/cc4915. View

Sood M, Rigatto C, Zarychanski R, Komenda P, Sood A, Bueti J . Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A(H1N1): report from a Canadian Province. Am J Kidney Dis. 2010; 55(5):848-55. PMC: 7125797. DOI: 10.1053/j.ajkd.2010.01.011. View

10.

Webb S, Seppelt I . Pandemic (H1N1) 2009 influenza ("swine flu") in Australian and New Zealand intensive care. Crit Care Resusc. 2009; 11(3):170-2. View

11.

Cunningham E, Kohli R, Venuto R . Influenza-associated myoglobinuric renal failure. JAMA. 1979; 242(22):2428-9. View

12.

Davies A, Jones D, Bailey M, Beca J, Bellomo R, Blackwell N . Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome. JAMA. 2009; 302(17):1888-95. DOI: 10.1001/jama.2009.1535. View

13.

Perez-Padilla R, Rosa-Zamboni D, Ponce de Leon S, Hernandez M, Quinones-Falconi F, Bautista E . Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med. 2009; 361(7):680-9. DOI: 10.1056/NEJMoa0904252. View

14.

Bagshaw S, George C, Dinu I, Bellomo R . A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients. Nephrol Dial Transplant. 2007; 23(4):1203-10. DOI: 10.1093/ndt/gfm744. View

15.

Kumar A, Zarychanski R, Pinto R, Cook D, Marshall J, Lacroix J . Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA. 2009; 302(17):1872-9. DOI: 10.1001/jama.2009.1496. View

16.

Ostermann M, Chang R . Acute kidney injury in the intensive care unit according to RIFLE. Crit Care Med. 2007; 35(8):1837-43. DOI: 10.1097/01.CCM.0000277041.13090.0A. View

17.

Simon N, Rovner R, BERLIN B . Acute myoglobinuria associated with type A2 (Hong Kong) influenza. JAMA. 1970; 212(10):1704-5. View

18.

Raffo L . [Influenza A(H1N1) epidemic in Argentina. Experience in a National General Hospital (Hospital Nacional Alejandro Posadas)]. Medicina (B Aires). 2009; 69(4):393-423. View

19.

Shenouda A, HATCH F . Influenza A viral infection associated with acute renal failure. Am J Med. 1976; 61(5):697-702. DOI: 10.1016/0002-9343(76)90148-0. View

20.

Bellomo R, Ronco C, Kellum J, Mehta R, Palevsky P . Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care. 2004; 8(4):R204-12. PMC: 522841. DOI: 10.1186/cc2872. View