5-HT and the Immune System

Overview

Journal Curr Opin Pharmacol

Specialty Pharmacology

Date 2011 Mar 12

PMID 21393060

Citations 91

Authors

Gerard P Ahern

Affiliations

Soon will be listed here.

Abstract

The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subtypes in innate and adaptive immune cells. Furthermore, a recent paper describing the immune phenotype of 5-HT deficient mice is discussed.

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