Higher Parity Associated with Higher Risk of Death from Gastric Cancer

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2011 Mar 11

PMID 21390150

Citations 5

Authors

Chih-Ching Chang

Chih-Cheng Chen

Hui-Fen Chiu

Chun-Yuh Yang

Affiliations

Soon will be listed here.

Abstract

Aim: To examine the association between parity and gastric cancer (the cases are almost all premenopausal women) risk in a cohort of young parous women.

Methods: The study cohort consisted of all women with a record of a first and singleton childbirth in the Birth Register between 1978 and 1987. We tracked each woman from the time of her first childbirth to December 31, 2008. Their vital status was ascertained by linking records to the computerized mortality database. Cox proportional hazard regression models were used to estimate hazard ratios of death from gastric cancer associated with parity.

Results: There were 1090 gastric cancer deaths (85.87% of them were premenopausal) during 33 686 828 person-years of follow-up. The mortality rate of gastric cancer was 3.24 cases per 100,000 person-years. A trend of increasing risk of gastric cancer was seen with increasing parity. The adjusted hazard ratio was 1.24 [confidence interval (95% CI): 1.02-1.50] for women who had borne two to three children, and 1.32 (95% CI: 1.01-1.72) for women with four or more births, when compared with women who had given birth to only one child.

Conclusion: These results suggest that higher parity may increase the risk of death from gastric cancer among premenopausal women.

Citing Articles

Mortality risk factors in patients with gastric cancer using Bayesian and ordinary Lasso logistic models: a study in the Southeast of Iran.

Hosseinnataj A, RezaBaneshi M, Bahrampour A Gastroenterol Hepatol Bed Bench. 2020; 13(1):31-36.

PMID: 32190222 PMC: 7069537.

Parity Differently Affects the Breast Cancer Specific Survival from Ductal Carcinoma In Situ to Invasive Cancer: A Registry-Based Retrospective Study from Korea.

Lee J, Oh M, Ko S, Park C, Lee E, Kim H Breast Cancer (Auckl). 2019; 13:1178223418825134.

PMID: 30728717 PMC: 6350119. DOI: 10.1177/1178223418825134.

Parity and gastric cancer risk: a systematic review and dose-response meta-analysis of prospective cohort studies.

Chen J, Gong T, Wu Q Sci Rep. 2016; 6:18766.

PMID: 26727146 PMC: 4698715. DOI: 10.1038/srep18766.

Mortality from cancers of the digestive system among grand multiparous women in Taiwan.

Chen B, Yang C Int J Environ Res Public Health. 2014; 11(4):4374-83.

PMID: 24758892 PMC: 4024986. DOI: 10.3390/ijerph110404374.

Sex hormones, hormonal interventions, and gastric cancer risk: a meta-analysis.

Camargo M, Goto Y, Zabaleta J, Morgan D, Correa P, Rabkin C Cancer Epidemiol Biomarkers Prev. 2011; 21(1):20-38.

PMID: 22028402 PMC: 3315355. DOI: 10.1158/1055-9965.EPI-11-0834.

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