Perinatal and Early Life Risk Factors for Inflammatory Bowel Disease

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2011 Mar 11

PMID 21390144

Citations 25

Authors

Stephen E Roberts

Clare J Wotton

John G Williams

Myfanwy Griffith

Michael J Goldacre

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate associations between perinatal risk factors and subsequent inflammatory bowel disease (IBD) in children and young adults.

Methods: Record linked abstracts of birth registrations, maternity, day case and inpatient admissions in a defined population of southern England. Investigation of 20 perinatal factors relating to the maternity or the birth: maternal age, Crohn's disease (CD) or ulcerative colitis (UC) in the mother, maternal social class, marital status, smoking in pregnancy, ABO blood group and rhesus status, pre-eclampsia, parity, the infant's presentation at birth, caesarean delivery, forceps delivery, sex, number of babies delivered, gestational age, birthweight, head circumference, breastfeeding and Apgar scores at one and five minutes.

Results: Maternity records were present for 180 children who subsequently developed IBD. Univariate analysis showed increased risks of CD among children of mothers with CD (P = 0.011, based on two cases of CD in both mother and child) and children of mothers who smoked during pregnancy. Multivariate analysis confirmed increased risks of CD among children of mothers who smoked (odds ratio = 2.04, 95% CI = 1.06-3.92) and for older mothers aged 35+ years (4.81, 2.32-9.98). Multivariate analysis showed that there were no significant associations between CD and 17 other perinatal risk factors investigated. It also showed that, for UC, there were no significant associations with the perinatal factors studied.

Conclusion: This study shows an association between CD in mother and child; and elevated risks of CD in children of older mothers and of mothers who smoked.

Citing Articles

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Pregnancy period and early-life risk factors for inflammatory bowel disease: a Northern Finland birth cohort 1966 study.

Blomster T, Koivurova O, Koskela R, Herzig K, Talley N, Ronkainen J BMC Public Health. 2024; 24(1):1038.

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An Overview of the Influence of Breastfeeding on the Development of Inflammatory Bowel Disease.

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Childhood Socioeconomic Characteristics and Risk of Inflammatory Bowel Disease: A Scandinavian Birth Cohort Study.

Sigvardsson I, Stordal K, Ostensson M, Guo A, Ludvigsson J, Marild K Inflamm Bowel Dis. 2023; 30(10):1801-1811.

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Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers.

Lokossou G, Kouakanou L, Schumacher A, Zenclussen A Front Immunol. 2022; 13:849012.

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