Genetic Correlation and Gene-environment Interaction Between Alcohol Problems and Educational Level in Young Adulthood

Overview

Journal J Stud Alcohol Drugs

Specialty Psychiatry

Date 2011 Mar 11

PMID 21388594

Citations 14

Authors

Antti Latvala

Danielle M Dick

Annamari Tuulio-Henriksson

Jaana Suvisaari

Richard J Viken

Richard J Rose

Jaakko Kaprio

Affiliations

Soon will be listed here.

Abstract

Objective: A lower level of education often co-occurs with alcohol problems, but factors underlying this co-occurrence are not well understood. Specifically, whether these outcomes share part of their underlying genetic influences has not been widely studied. Educational level also reflects various environmental influences that may moderate the genetic etiology of alcohol problems, but gene-environment interactions between educational attainment and alcohol problems are unknown.

Method: We studied the two non-mutually exclusive possibilities of common genetic influences and gene-environment interaction between alcohol problems and low education using a population-based sample (n = 4,858) of Finnish young adult twins (M(age) = 24.5 years, range: 22.8-28.6 years). Alcohol problems were assessed with the Rutgers Alcohol Problem Index and self-reported maximum number of drinks consumed in a 24-hour period. Years of education, based on completed and ongoing studies, represented educational level.

Results: Educational level was inversely associated with alcohol problems in young adulthood, and this association was most parsimoniously explained by overlapping genetic influences. Independent of this co-occurrence, higher education was associated with increased relative importance of genetic influences on alcohol problems, whereas environmental factors had a greater effect among twins with lower education.

Conclusions: Our findings suggest a complex relationship between educational level and alcohol problems in young adulthood. Lower education is related to higher levels of alcohol problems, and this co-occurrence is influenced by genetic factors affecting both phenotypes. In addition, educational level moderates the importance of genetic and environmental influences on alcohol problems, possibly reflecting differences in social-control mechanisms related to educational level.

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References

Swendsen J, Conway K, Degenhardt L, Dierker L, Glantz M, Jin R . Socio-demographic risk factors for alcohol and drug dependence: the 10-year follow-up of the national comorbidity survey. Addiction. 2009; 104(8):1346-55. PMC: 2794245. DOI: 10.1111/j.1360-0443.2009.02622.x. View

Conger R, Donnellan M . An interactionist perspective on the socioeconomic context of human development. Annu Rev Psychol. 2006; 58:175-99. DOI: 10.1146/annurev.psych.58.110405.085551. View

Pitkanen T, Kokko K, Lyyra A, Pulkkinen L . A developmental approach to alcohol drinking behaviour in adulthood: a follow-up study from age 8 to age 42. Addiction. 2008; 103 Suppl 1:48-68. DOI: 10.1111/j.1360-0443.2008.02176.x. View

Rathouz P, Van Hulle C, Rodgers J, Waldman I, Lahey B . Specification, testing, and interpretation of gene-by-measured-environment interaction models in the presence of gene-environment correlation. Behav Genet. 2008; 38(3):301-15. PMC: 2758248. DOI: 10.1007/s10519-008-9193-4. View

Agrawal A, Lynskey M . Are there genetic influences on addiction: evidence from family, adoption and twin studies. Addiction. 2008; 103(7):1069-81. DOI: 10.1111/j.1360-0443.2008.02213.x. View

Lager A, Bremberg S, Vagero D . The association of early IQ and education with mortality: 65 year longitudinal study in Malmö, Sweden. BMJ. 2009; 339:b5282. PMC: 2792333. DOI: 10.1136/bmj.b5282. View

Baker L, Treloar S, Reynolds C, Heath A, Martin N . Genetics of educational attainment in Australian twins: sex differences and secular changes. Behav Genet. 1996; 26(2):89-102. DOI: 10.1007/BF02359887. View

McCaffery J, Papandonatos G, Lyons M, Koenen K, Tsuang M, Niaura R . Educational attainment, smoking initiation and lifetime nicotine dependence among male Vietnam-era twins. Psychol Med. 2007; 38(9):1287-97. PMC: 2532060. DOI: 10.1017/S0033291707001882. View

Gottfredson L . Intelligence: is it the epidemiologists' elusive "fundamental cause" of social class inequalities in health?. J Pers Soc Psychol. 2004; 86(1):174-99. DOI: 10.1037/0022-3514.86.1.174. View

10.

Koopmans J, Slutske W, van Baal G, Boomsma D . The influence of religion on alcohol use initiation: evidence for genotype X environment interaction. Behav Genet. 2000; 29(6):445-53. DOI: 10.1023/a:1021679005623. View

11.

van der Zwaluw C, Engels R . Gene-environment interactions and alcohol use and dependence: current status and future challenges. Addiction. 2009; 104(6):907-14. DOI: 10.1111/j.1360-0443.2009.02563.x. View

12.

Saccone S, Saccone N, Neuman R, Rice J . Genetic analysis of the maximum drinks phenotype. BMC Genet. 2006; 6 Suppl 1:S124. PMC: 1866813. DOI: 10.1186/1471-2156-6-S1-S124. View

13.

Timberlake D, Hopfer C, Rhee S, Friedman N, Haberstick B, Lessem J . College attendance and its effect on drinking behaviors in a longitudinal study of adolescents. Alcohol Clin Exp Res. 2007; 31(6):1020-30. DOI: 10.1111/j.1530-0277.2007.00383.x. View

14.

Rose R, Dick D, Viken R, Kaprio J . Gene-environment interaction in patterns of adolescent drinking: regional residency moderates longitudinal influences on alcohol use. Alcohol Clin Exp Res. 2001; 25(5):637-43. View

15.

Gallo L, Smith T, Cox C . Socioeconomic status, psychosocial processes, and perceived health: an interpersonal perspective. Ann Behav Med. 2006; 31(2):109-19. DOI: 10.1207/s15324796abm3102_2. View

16.

Dick D, Bernard M, Aliev F, Viken R, Pulkkinen L, Kaprio J . The role of socioregional factors in moderating genetic influences on early adolescent behavior problems and alcohol use. Alcohol Clin Exp Res. 2009; 33(10):1739-48. PMC: 3594846. DOI: 10.1111/j.1530-0277.2009.01011.x. View

17.

Williams R . A note on robust variance estimation for cluster-correlated data. Biometrics. 2000; 56(2):645-6. DOI: 10.1111/j.0006-341x.2000.00645.x. View

18.

Jacobi F, Wittchen H, Holting C, Hofler M, Pfister H, Muller N . Prevalence, co-morbidity and correlates of mental disorders in the general population: results from the German Health Interview and Examination Survey (GHS). Psychol Med. 2004; 34(4):597-611. DOI: 10.1017/S0033291703001399. View

19.

Silventoinen K, Sarlio-Lahteenkorva S, Koskenvuo M, Lahelma E, Kaprio J . Effect of environmental and genetic factors on education-associated disparities in weight and weight gain: a study of Finnish adult twins. Am J Clin Nutr. 2004; 80(4):815-22. DOI: 10.1093/ajcn/80.4.815. View

20.

Rose R, Kaprio J, Winter T, Koskenvuo M, Viken R . Familial and socioregional environmental effects on abstinence from alcohol at age sixteen. J Stud Alcohol Suppl. 1999; 13:63-74. DOI: 10.15288/jsas.1999.s13.63. View