Pharmacodynamic Study of Polymerized Porcine Hemoglobin (pPolyHb) in a Rat Model of Exchange Transfusion

Overview

Journal Artif Cells Blood Substit Immobil Biotechnol

Publisher Informa Healthcare

Specialties Biomedical Engineering
Biotechnology
General Surgery

Date 2011 Mar 9

PMID 21381891

Citations 2

Authors

Hongli Zhu

Xiaodong Dang

Kunping Yan

Penggao Dai

Chao Luo

Jun Ma

Yan Li

Thomas Ming Swi Chang

Chao Chen

Affiliations

Soon will be listed here.

Abstract

The objective of the present study is to evaluate the pharmacodynamic properties of polymerized porcine hemoglobin (pPolyHb) in an exchange transfusion model. Each of two groups of rats received a volume of pPolyHb or hetastarch that equalled 120-140% of estimated total blood volume (70 ml/kg) exchange transfusion. The results showed pPolyHb retained hemodynamic stability and exhibited superior volume expansion capability. Furthermore, pPolyHb effectively reverse anaerobic metabolism caused by a large amount of volume exchange. In comparison with hetastarch, pPolyHb increased blood oxygen content and tissue oxygenation. All these properties contribute to a higher effectiveness in sustaining the lives of rats in pPolyHb group.

Citing Articles

Application of polymerized porcine hemoglobin in the normothermic machine perfusion of rat livers.

Li B, Zhang J, Shen C, Zong T, Zhao C, Zhao Y Front Bioeng Biotechnol. 2023; 10:1072950.

PMID: 36686244 PMC: 9854803. DOI: 10.3389/fbioe.2022.1072950.

Immune safety evaluation of polymerized porcine hemoglobin (pPolyHb): a potential red blood cell substitute.

Zhu H, Yan K, Dang X, Huang H, Chen E, Chen B Artif Cells Blood Substit Immobil Biotechnol. 2011; 39(6):398-405.

PMID: 22066797 PMC: 3584014. DOI: 10.3109/10731199.2011.631499.

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