Altered Small-world Brain Networks in Temporal Lobe in Patients with Schizophrenia Performing an Auditory Oddball Task

Overview

Journal Front Syst Neurosci

Specialty Neurology

Date 2011 Mar 4

PMID 21369355

Citations 50

Authors

Qingbao Yu

Jing Sui

Srinivas Rachakonda

Hao He

Godfrey Pearlson

Vince D Calhoun

Affiliations

Soon will be listed here.

Abstract

The functional architecture of the human brain has been extensively described in terms of complex networks characterized by efficient small-world features. Recent functional magnetic resonance imaging (fMRI) studies have found altered small-world topological properties of brain functional networks in patients with schizophrenia (SZ) during the resting state. However, little is known about the small-world properties of brain networks in the context of a task. In this study, we investigated the topological properties of human brain functional networks derived from fMRI during an auditory oddball (AOD) task. Data were obtained from 20 healthy controls and 20 SZ; A left and a right task-related network which consisted of the top activated voxels in temporal lobe of each hemisphere were analyzed separately. All voxels were detected by group independent component analysis. Connectivity of the left and right task-related networks were estimated by partial correlation analysis and thresholded to construct a set of undirected graphs. The small-worldness values were decreased in both hemispheres in SZ. In addition, SZ showed longer shortest path length and lower global efficiency only in the left task-related networks. These results suggested small-world attributes are altered during the AOD task-related networks in SZ which provided further evidences for brain dysfunction of connectivity in SZ.

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References

Bell A, Sejnowski T . An information-maximization approach to blind separation and blind deconvolution. Neural Comput. 1995; 7(6):1129-59. DOI: 10.1162/neco.1995.7.6.1129. View

Zhang Z, Lu G, Zhong Y, Tan Q, Yang Z, Liao W . Impaired attention network in temporal lobe epilepsy: a resting FMRI study. Neurosci Lett. 2009; 458(3):97-101. DOI: 10.1016/j.neulet.2009.04.040. View

Bassett D, Bullmore E . Human brain networks in health and disease. Curr Opin Neurol. 2009; 22(4):340-7. PMC: 2902726. DOI: 10.1097/WCO.0b013e32832d93dd. View

White T, Schmidt M, Kim D, Calhoun V . Disrupted functional brain connectivity during verbal working memory in children and adolescents with schizophrenia. Cereb Cortex. 2010; 21(3):510-8. PMC: 3105631. DOI: 10.1093/cercor/bhq114. View

Hampson M, Peterson B, Skudlarski P, Gatenby J, Gore J . Detection of functional connectivity using temporal correlations in MR images. Hum Brain Mapp. 2002; 15(4):247-62. PMC: 6872035. DOI: 10.1002/hbm.10022. View

Achard S, Salvador R, Whitcher B, Suckling J, Bullmore E . A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs. J Neurosci. 2006; 26(1):63-72. PMC: 6674299. DOI: 10.1523/JNEUROSCI.3874-05.2006. View

Calhoun V, Liu J, Adali T . A review of group ICA for fMRI data and ICA for joint inference of imaging, genetic, and ERP data. Neuroimage. 2008; 45(1 Suppl):S163-72. PMC: 2651152. DOI: 10.1016/j.neuroimage.2008.10.057. View

Calhoun V, Adali T, Pearlson G, Pekar J . A method for making group inferences from functional MRI data using independent component analysis. Hum Brain Mapp. 2001; 14(3):140-51. PMC: 6871952. DOI: 10.1002/hbm.1048. View

Stam C . Functional connectivity patterns of human magnetoencephalographic recordings: a 'small-world' network?. Neurosci Lett. 2004; 355(1-2):25-8. DOI: 10.1016/j.neulet.2003.10.063. View

10.

Bramon E, Rabe-Hesketh S, Sham P, Murray R, Frangou S . Meta-analysis of the P300 and P50 waveforms in schizophrenia. Schizophr Res. 2004; 70(2-3):315-29. DOI: 10.1016/j.schres.2004.01.004. View

11.

Lynall M, Bassett D, Kerwin R, McKenna P, Kitzbichler M, Muller U . Functional connectivity and brain networks in schizophrenia. J Neurosci. 2010; 30(28):9477-87. PMC: 2914251. DOI: 10.1523/JNEUROSCI.0333-10.2010. View

12.

Calhoun V, Maciejewski P, Pearlson G, Kiehl K . Temporal lobe and "default" hemodynamic brain modes discriminate between schizophrenia and bipolar disorder. Hum Brain Mapp. 2007; 29(11):1265-75. PMC: 2665178. DOI: 10.1002/hbm.20463. View

13.

Meyer-Lindenberg A . From maps to mechanisms through neuroimaging of schizophrenia. Nature. 2010; 468(7321):194-202. DOI: 10.1038/nature09569. View

14.

ODonnell B, Vohs J, Hetrick W, Carroll C, Shekhar A . Auditory event-related potential abnormalities in bipolar disorder and schizophrenia. Int J Psychophysiol. 2004; 53(1):45-55. DOI: 10.1016/j.ijpsycho.2004.02.001. View

15.

Freire L, Roche A, Mangin J . What is the best similarity measure for motion correction in fMRI time series?. IEEE Trans Med Imaging. 2002; 21(5):470-84. DOI: 10.1109/TMI.2002.1009383. View

16.

Calhoun V, Kiehl K, Liddle P, Pearlson G . Aberrant localization of synchronous hemodynamic activity in auditory cortex reliably characterizes schizophrenia. Biol Psychiatry. 2004; 55(8):842-9. PMC: 2771440. DOI: 10.1016/j.biopsych.2004.01.011. View

17.

Wang L, Metzak P, Honer W, Woodward T . Impaired efficiency of functional networks underlying episodic memory-for-context in schizophrenia. J Neurosci. 2010; 30(39):13171-9. PMC: 6633526. DOI: 10.1523/JNEUROSCI.3514-10.2010. View

18.

van Dellen E, Douw L, Baayen J, Heimans J, Ponten S, Vandertop W . Long-term effects of temporal lobe epilepsy on local neural networks: a graph theoretical analysis of corticography recordings. PLoS One. 2009; 4(11):e8081. PMC: 2778557. DOI: 10.1371/journal.pone.0008081. View

19.

Watts D, Strogatz S . Collective dynamics of 'small-world' networks. Nature. 1998; 393(6684):440-2. DOI: 10.1038/30918. View

20.

van den Heuvel M, Hulshoff Pol H . Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol. 2010; 20(8):519-34. DOI: 10.1016/j.euroneuro.2010.03.008. View